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Merck

692905

Sigma-Aldrich

N-Ethyl-d5-maleimide

99 atom % D, 98% (CP)

别名:

NEM (ethyl-d5)

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About This Item

经验公式(希尔记法):
C6D5H2NO2
分子量:
130.16
MDL號碼:
分類程式碼代碼:
12352005
PubChem物質ID:
NACRES:
NA.13

同位素純度

99 atom % D

品質等級

化驗

98% (CP)

形狀

powder

mp

43-46 °C (lit.)

質量偏移

M+5

儲存溫度

2-8°C

SMILES 字串

[2H]C([2H])([2H])C([2H])([2H])N1C(=O)C=CC1=O

InChI

1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3/i1D3,2D2

InChI 密鑰

HDFGOPSGAURCEO-ZBJDZAJPSA-N

一般說明

N-Ethyl-d5-maleimide is a deuterated isotope analog of N-ethymaleimide, wherein methylene and methyl protons are replaced by deuterium.

應用

N-Ethyl-d5-maleimide can be used:
  • To synthesize isotopic silica nanotag by reacting with silica precursor 3-mercaptopropyltrimethoxysilane (MPTMS) for multiplexed ion beam imaging.
  • As an isotopic internal standard to determine the ratio of glutathione (GSH) and glutathione disulfide (GSSG) in cultured cells using HPLC-UV and LC-QTOF-MS.

包裝

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

象形圖

Skull and crossbonesCorrosion

訊號詞

Danger

危險分類

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

163.4 °F - closed cup

閃點(°C)

73 °C - closed cup


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Optimized Protocol for the In Situ Derivatization of Glutathione with N-Ethylmaleimide in Cultured Cells and the Simultaneous Determination of Glutathione/Glutathione Disulfide Ratio by HPLC-UV-QTOF-MS
Sun X, et al.
Metabolites, 10(7), 292-292 (2020)
Xueni Sun et al.
Metabolites, 10(7) (2020-07-28)
Glutathione (GSH) and glutathione disulfide (GSSG) are commonly used to assess the oxidative status of a biological system. Various protocols are available for the analysis of GSH and GSSG in biomedical specimens. In this study, we present an optimized protocol
Stefan Harmsen et al.
Advanced materials technologies, 5(7) (2020-07-15)
High-dimensional profiling of markers and analytes using approaches, such as barcoded fluorescent imaging with repeated labeling and mass cytometry has allowed visualization of biological processes at the single-cell level. To address limitations of sensitivity and mass-channel capacity, a nanobarcoding platform
T R Sutton et al.
Redox biology, 16, 359-380 (2018-04-09)
Several diseases are associated with perturbations in redox signaling and aberrant hydrogen sulfide metabolism, and numerous analytical methods exist for the measurement of the sulfur-containing species affected. However, uncertainty remains about their concentrations and speciation in cells/biofluids, perhaps in part
Isotopically Encoded Nanotags for Multiplexed Ion Beam Imaging
Harmsen S, et al.
Advanced Materials Technologies, 5(7), 2000098-2000098 (2020)

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