910058

2-(2-(Oct-7-yn-1-yloxy)ethoxy)acetic acid

≥95%

• Synonyme(s) : 2-2-6 PROTAC^® linker, Alkyne-PEG₂-acid, Bifunctional linker
• Formule empirique (notation de Hill): C₁₂H₂₀O₄
• Poids moléculaire : 228.28
• Code UNSPSC : 12352106

Propriétés

• Pureté: ≥95%
• Forme: (Viscous Liquid or Semi-solid or Paste or Solid)
• Capacité de réaction: reaction type: click chemistry
• Pertinence de la réaction: reagent type: linker
• Groupe fonctionnel: alkyne; carboxylic acid
• Température de stockage: 2-8°C
• Chaîne SMILES: OC(COCCOCCCCCCC#C)=O

Description

Application

This heterobifunctional, PEGylated crosslinker 2-(2-(oct-7-yn-1-yloxy)ethoxy)acetic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG₂-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-6.

Autres remarques

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable