901572

Bromo-PEG₂-acid

≥95%

• Formule empirique (notation de Hill): C₇H₁₃BrO₄
• Numéro CAS: 1807503-92-9
• Poids moléculaire : 241.08
• Numéro MDL: MFCD28122969
• Code UNSPSC : 12352101
• Nomenclature NACRES : NA.22

Propriétés

• Pureté: ≥95%
• Forme: liquid
• Pertinence de la réaction: reagent type: linker
• Groupe fonctionnel: bromo; carboxylic acid
• Température de stockage: −20°C
• Chaîne SMILES: BrCCOCCOCCC(O)=O

Description

Application

Bromo-PEG₂-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG₂-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

This is a crosslinker with a bromo group on one end and a carboxyl group on the other end. The compound contains two PEG units to help improve solubility.

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3