909998

2-(2-((7-(tert-Butoxy)-7-oxoheptyl)oxy)ethoxy)acetic acid

≥95%

• Synonyme(s) : 2-2-6 PROTAC^® linker, Bifunctional linker, OtBu-PEG₂-acid
• Formule empirique (notation de Hill): C₁₅H₂₈O₆
• Poids moléculaire : 304.38
• Code UNSPSC : 12352200

Propriétés

• Pureté: ≥95%
• Forme: liquid
• Pertinence de la réaction: reagent type: linker
• Groupe fonctionnel: carboxylic acid; ester
• Température de stockage: 2-8°C
• Chaîne SMILES: CC(C)(OC(CCCCCCOCCOCC(O)=O)=O)C

Description

Application

This heterobifunctional, PEGylated crosslinker 2-(2-((7-(tert-butoxy)-7-oxoheptyl)oxy)ethoxy)acetic acid features a carboxyl group at one end and a t-butyl protected carboxylic acid at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. The linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-6.

Autres remarques

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable