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SML0031

Sigma-Aldrich

DBeQ

≥98% (HPLC)

Synonym(e):

JRF 12, N2,N4-dibenzylquinazoline-2,4-diamine

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About This Item

Empirische Formel (Hill-System):
C22H20N4
CAS-Nummer:
177355-84-9
Molekulargewicht:
340.42
MDL-Nummer:
MFCD03691820
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825101
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: ≥20 mg/mL

Lagertemp.

room temp

SMILES String

C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4

InChI

1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)

InChIKey

QAIMUUJJAJBPCL-UHFFFAOYSA-N

Anwendung

HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.

Biochem./physiol. Wirkung

DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Analysenzertifikate (COA)

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Holger W Auner et al.
PloS one, 8(9), e74415-e74415 (2013-09-27)
Inhibition of the proteasome is a widely used strategy for treating multiple myeloma that takes advantage of the heavy secretory load that multiple myeloma cells (MMCs) have to deal with. Resistance of MMCs to proteasome inhibition has been linked to
Ainoa Figuerola-Conchas et al.
ACS chemical biology, 15(1), 243-253 (2019-12-04)
VCP/p97 belongs to the AAA+ ATPase family and has an essential role in several cellular processes ranging from cell division to protein homeostasis. Compounds targeting p97 inhibit the main ATPase domain and cause cell death. Here, using PNA-encoded chemical libraries
Katrin Schweitzer et al.
Journal of cellular and molecular medicine, 20(1), 58-70 (2015-10-16)
Cullin-RING-ubiquitin-ligase (CRL)-dependent ubiquitination of the nuclear factor kappa B (NF-κB) inhibitor IκBα and its subsequent degradation by the proteasome usually precede NF-κB/RelA nuclear activity. Through removal of the CRL-activating modification of their cullin subunit with the ubiquitin (Ub)-like modifier NEDD8
Wenchun Fan et al.
Antiviral research, 127, 32-40 (2016-01-19)
The tripartite motif protein 21 (TRIM21) is a ubiquitously expressed E3 ubiquitin ligase and an intracellular antibody receptor. TRIM21 mediates antibody-dependent intracellular neutralization (ADIN) in cytosol and provides an intracellular immune response to protect host defense against pathogen infection. In
Aparna Shinde et al.
Cancer research, 79(8), 1831-1843 (2019-02-09)
The ability of breast cancer cells to transiently transition between epithelial and mesenchymal states contributes to their metastatic potential. Therefore, driving tumor cells into a stable mesenchymal state, as opposed to complete tumor cell eradication, presents an opportunity to pharmacologically
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