H9538

HNE-DMA

hexane solution, ≥85% (GC)

• Synonym(e): (E)-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA
• Empirische Formel (Hill-System): C₁₁H₂₂O₃
• Molekulargewicht: 202.29
• MDL-Nummer: MFCD07370138
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724506
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥85% (GC)
• Form: hexane solution
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: CCCCCC(O)\C=C\C(OC)OC
• InChI: 1S/C11H22O3/c1-4-5-6-7-10(12)8-9-11(13-2)14-3/h8-12H,4-7H2,1-3H3/b9-8+
• InChIKey: ATGIHMSJAARJTF-CMDGGOBGSA-N

Beschreibung

Biochem./physiol. Wirkung

Stable form of HNE; toxic second messenger of free radicals.

Angaben zur Herstellung

To prepare HNE from HNE-DMA: evaporate the hexane under a gentle stream of nitrogen at room temperature. Working at 4 °C, add 1 ml (5 mg size) or 0.4 ml (2 mg size) of 1 mM cold HCl and stir for 45 minutes, or alternatively, close the vial and shake for 30 minutes. Upon hydrolysis, the initially cloudy solution becomes almost clear. This solution now has a pH of ∼3, contains ∼5 mg (5 mg size) or ∼2 mg (2 mg size) of the aldehyde (HNE), and is stable for at least 24 hours if kept at 4 °C. 6.8 mg HNE-DMA in 1 mL of hexane solution, giving 5 mg of HNE after hydrolysis.It is recommended that the freshly prepared HNE solution be used immediately.

Sicherheitshinweise

• Piktogramme: GHS02,GHS08,GHS07,GHS09
• Signalwort: Danger
• H-Sätze: H225,H304,H315,H336,H361f,H372,H411
• P-Sätze: P202 - P210 - P273 - P301 + P310 - P303 + P361 + P353 - P331
• Gefahreneinstufungen: Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Inhalation - STOT SE 3
• Zielorgane: Central nervous system, Nervous system
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): -14.8 °F - closed cup
• Flammpunkt (°C): -26 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter