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G002

Sigma-Aldrich

Isoguvacine hydrochloride

solid

Synonym(e):

1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride

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About This Item

Empirische Formel (Hill-System):
C6H9NO2 · HCl
CAS-Nummer:
68547-97-7
Molekulargewicht:
163.60
MDL-Nummer:
MFCD00055192
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278160
NACRES:
NA.77

Form

solid

Qualitätsniveau

200

Farbe

white

Löslichkeit

H2O: soluble (refrigerate if not used immediately.)
methanol: slightly soluble
neutral and acidic solutions: stable (in basic solutions the free amine can oxidize easily)

SMILES String

Cl[H].OC(=O)C1=CCNCC1

InChI

1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H

InChIKey

SUWREQRNTXCCBL-UHFFFAOYSA-N

Angaben zum Gen

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562)

Anwendung

Isoguvacine hydrochloride has been used as a γ-aminobutyric acid type A (GABAA) receptor agonist:
  • to study its effects on neuronal activity in rats
  • to study its antiallodynic effect in rats
  • to study its effects on baroreflex gains in rats

Biochem./physiol. Wirkung

Isoguvacine is a strong γ-aminobutyric acid A (GABAA) receptor agonist.

Leistungsmerkmale und Vorteile

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000424663
0000424661
0000424661
0000424663
0000417357

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SR-95531 ≥98% (HPLC), powder

Sigma-Aldrich

S106

SR-95531

Hellma® Makro-Küvetten für Absorptionsmessungen, Standardzellen High Performance Quartz Glass, spectral range 200-2,500 nm, pathlength 10 mm, chamber volume 3,500 μL

Z600091

Hellma® Makro-Küvetten für Absorptionsmessungen, Standardzellen

(+)-Bicucullin ≥97.0% (TLC)

Sigma-Aldrich

14340

(+)-Bicucullin

Frederik Rode et al.
European journal of pharmacology, 516(2), 131-138 (2005-06-07)
Gamma aminobutyric acid (GABA) plays a major role in the central hyperexcitabilty associated with nerve damage. The precise antinociceptive actions mediated by GABA(A) receptor agonists remain unclear as previous studies have shown mixed results in neuropathic pain models. Thus, various
Biochemical pharmacology of GABAergic agonists.
S J Enna et al.
Life sciences, 24(19), 1727-1737 (1979-05-07)
J W Polson et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 293(5), R1954-R1960 (2007-09-07)
Microinjection of angiotensin II into the nucleus tractus solitarii attenuates the baroreceptor reflex-mediated bradycardia by inhibiting both vagal and cardiac sympathetic components. However, it is not known whether the baroreflex modulation of other sympathetic outputs (i.e., noncardiac) also are inhibited
Mathias Dutschmann et al.
The European journal of neuroscience, 24(4), 1071-1084 (2006-08-26)
Lesion or pharmacological manipulation of the dorsolateral pons can transform the breathing pattern to apneusis (pathological prolonged inspiration). Apneusis reflects a disturbed inspiratory off-switch mechanism (IOS) leading to a delayed phase transition from inspiration to expiration. Under intact conditions the
Kai Y Fan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(40), 13718-13728 (2012-10-05)
The symptoms of Parkinson's disease (PD) are related to changes in the frequency and pattern of activity in the reciprocally connected GABAergic external globus pallidus (GPe) and glutamatergic subthalamic nucleus (STN). In idiopathic and experimental PD, the GPe and STN
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