M1523

Muscimol

≥98% (TLC), powder, GABAA receptor agonist.

• Synonym(e): 3-Hydroxy-5-aminomethyl-isoxazol, 5-Aminomethyl-3-hydroxy-isoxazol, 5-Aminomethyl-3-isoxazolol, Agarin, Pantherin
• Empirische Formel (Hill-System): C₄H₆N₂O₂
• CAS-Nummer: 2763-96-4
• Molekulargewicht: 114.10
• Beilstein: 1618960
• EG-Nummer: 220-430-4
• MDL-Nummer: MFCD00057894
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24896662
• NACRES: NA.77

Eigenschaften

• product name: Muscimol, powder
• Form: powder
• Qualitätsniveau: 200
• Farbe: white to off-white
• Lagertemp.: 2-8°C
• SMILES String: NCC1=CC(=O)NO1
• InChI: 1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
• InChIKey: ZJQHPWUVQPJPQT-UHFFFAOYSA-N
• Angaben zum Gen: rat ... Gabra2(29706)

Beschreibung

Allgemeine Beschreibung

Muscimol is a psychoactive isoxazole component, which is found in Amanita muscaria and related mushrooms. It lowers cerebral glucose metabolism and increases the level of 5-hydroxytryptamine in brain. Muscimol has hallucinogenic effects. It is associated with distorted perceptions, nausea and vomiting.

Anwendung

Muscimol has been used:

• to reduce conditioned fear-expression in lateral amygdala (LA)
• to eliminate cortical cell response in ferrets
• to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in zebra finches

Biochem./physiol. Wirkung

GABA_A-Rezeptor-Agonist

Leistungsmerkmale und Vorteile

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H300,H336
• P-Sätze: P261 - P264 - P271 - P301 + P310 - P304 + P340 + P312 - P403 + P233
• Gefahreneinstufungen: Acute Tox. 2 Oral - STOT SE 3
• Zielorgane: Central nervous system
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges