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F2552

Sigma-Aldrich

Formestan

solid

Synonym(e):

4-Hydroxyandrost-4-en-3,17-dion

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About This Item

Empirische Formel (Hill-System):
C19H26O3
CAS-Nummer:
566-48-3
Molekulargewicht:
302.41
MDL-Nummer:
MFCD00057814
UNSPSC-Code:
12352204
PubChem Substanz-ID:
24894827
NACRES:
NA.25

Biologische Quelle

synthetic (organic)

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Löslichkeit

chloroform: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

Anwendung(en)

forensics and toxicology
veterinary

Lagertemp.

2-8°C

SMILES String

C[C@]12CC[C@H]3[C@@H](CCC4=C(O)C(=O)CC[C@]34C)[C@@H]1CCC2=O

InChI

1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1

InChIKey

OSVMTWJCGUFAOD-KZQROQTASA-N

Angaben zum Gen

human ... CYP19A1(1588)

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Biochem./physiol. Wirkung

Aromatase inhibitor used as an anti-cancer agent against estrogen-dependent tumors.

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H360

Gefahreneinstufungen

Repr. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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Jie Wang et al.
Frontiers in systems neuroscience, 14, 546531-546531 (2020-10-06)
In rodents, the period of increased vulnerability to the developmental effects of general anesthetics coincides with the period of age-specific organizing (masculinizing) effects of the major female sex hormone 17β-estradiol (E2) in the male brain and excitatory GABA type A
Adam T Cawley et al.
Rapid communications in mass spectrometry : RCM, 22(24), 4147-4157 (2008-11-26)
Studies have shown that the administration of androstenedione (ADIONE) significantly increases the urinary ratio of testosterone glucuronide to epitestosterone glucuronide (T/E) - measured by gas chromatography/mass spectrometry (GC/MS) - in subjects with a normal ( approximately 1) or naturally high
Lucía Martínez-Mota et al.
Pharmacology, biochemistry, and behavior, 88(3), 332-340 (2007-10-05)
In male rats, the antidepressant-like effect of fluoxetine (FLX) and desipramine (DMI) in the forced swimming test (FST) is reduced by orchidectomy and partially restored by testosterone (T). It is unknown if this modulation of T is produced by its
L R Wiseman et al.
Drugs, 45(1), 66-84 (1993-01-01)
Formestane (4-hydroxyandrostenedione) is an effective and competitive inhibitor of aromatase, the enzyme responsible for the conversion of androgens to estrone and estradiol. Significant reductions in plasma estradiol levels are observed following intramuscular administration of formestane to postmenopausal women with advanced
Xin Wang et al.
Cancer research, 66(21), 10281-10286 (2006-11-03)
Using Western blot as the major technique, we studied the effects of the three Food and Drug Administration (FDA)-approved aromatase inhibitors (AI) on aromatase protein stability in the aromatase-overexpressing breast cancer cell line MCF-7aro. We have found that exemestane treatment
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