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Merck

A5222

Sigma-Aldrich

D-Aminosäure-Oxidase aus Schweineniere

powder, ≥1.5 units/mg solid

Synonym(e):

D-AAO, D-Aminosäure: Sauerstoff Oxidoreduktase

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About This Item

CAS-Nummer:
EC-Nummer:
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352204
NACRES:
NA.54
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Form

powder

Qualitätsniveau

Spezifische Aktivität

≥1.5 units/mg solid

Lagertemp.

−20°C

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Anwendung

D-amino acid oxidase (DAO) is a potential target molecule for the treatment of chronic pain and schizophrenia [1][2]. D-amino acid oxidase is used to oxidize D-amino acids to their corresponding imino acids.

Einheitendefinition

One unit will oxidatively deaminate 1.0 μmole of D-alanine to pyruvate per minute at pH 8.3 at 25 °C, in the presence of a catalase.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Cindy J Lee et al.
Metabolites, 12(9) (2022-09-24)
The pancreatic islets of Langerhans are clusters of cells that function as endocrine units synthesizing and releasing insulin and a range of additional peptide hormones. The structural and chemical characteristics of islets change during type 2 diabetes development. Although a
Andrea V Canosa et al.
Scientific reports, 8(1), 9016-9016 (2018-06-15)
Serine racemase (SR) catalyses two reactions: the reversible racemisation of L-serine and the irreversible dehydration of L- and D-serine to pyruvate and ammonia. SRs are evolutionarily related to serine dehydratases (SDH) and degradative threonine deaminases (TdcB). Most SRs and TdcBs
Pamela Cappelletti et al.
The FEBS journal, 281(3), 708-723 (2013-11-19)
Human D-amino acid oxidase (EC 1.4.3.3; hDAAO) is a peroxisomal flavoenzyme significantly enriched in the mammalian brain. hDAAO has been proposed to play (with serine racemase; EC 5.1.1.18) an essential role in the catabolism of D-serine, an 'atypical' key signalling
Makoto Yoshimoto et al.
Enzyme and microbial technology, 52(1), 13-19 (2012-12-04)
Oligolamellar phospholipid vesicles incorporated with d-amino acid oxidase from porcine kidney (OV-DAO) were prepared by encapsulating pre-formed enzyme-bound unilamellar vesicles (UV-DAO) with bilayers of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC). The bilayer of UV-DAO was composed of POPC, 30 mol% of cholesterol and 15
Seth C Hopkins et al.
The Journal of pharmacology and experimental therapeutics, 345(3), 502-511 (2013-03-23)
Inhibition of d-amino acid oxidase (DAAO) activity is a potential target for the treatment of chronic pain. Here we characterized the effects of systemic administration of the DAAO inhibitor 4H-furo[3,2-b]pyrrole-5-carboxylic acid (SUN) in rat models of neuropathic and inflammatory pain.

Questions

  1. Hello, I am doing my research about D-amino acid oxidase from porcine kidney. For further calculations I need molar extinction coefficient of pkDAAO. Maybe You have bigger description or some kind of information about it? Thank You.

    1 answer
    1. There are two extinction coefficient values available:

      Assuming all Cys residues form cystines - 1.935 at 280 nm in water, 0.1% (1 g/L)
      Assuming all Cys residues are reduced - 1.929 at 280 nm in water, 0.1% (1 g/L)

      Please see the link below to review this and additional information available at Expasy:
      https://web.expasy.org/cgi-bin/protparam/protparam1?P00371@noft@

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