454863

D-erythro-MAPP

A synthetic analog of ceramide.

• Synonym(e): D-erythro-MAPP, (1S,2R)-D- erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol, AC Inhibitor II, Acid Ceramidase Inhibitor II, D-e-MAPP, (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol, AC Inhibitor II, Acid Ceramidase Inhibitor II, D-e-MAPP
• Empirische Formel (Hill-System): C₂₃H₃₉NO₂
• CAS-Nummer: 143492-38-0
• Molekulargewicht: 361.56
• UNSPSC-Code: 12352211

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (NMR)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze
• Löslichkeit: ethanol: 5 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C23H39NO2/c1-3-4-5-6-7-8-9-10-11-12-16-19-22(25)24-20(2)23(26)21-17-14-13-15-18-21/h13-15,17-18,20,23,26H,3-12,16,19H2,1-2H3,(H,24,25)/t20-,23-/m1/s1
• InChIKey: YLAZEWZHIRBZDA-NFBKMPQASA-N

Beschreibung

Allgemeine Beschreibung

A synthetic analog of ceramide. Shown to selectively inhibit alkaline ceramidase both in vitro and in HL-60 cells (IC₅₀ = 1-5 µM for alkaline ceramidase versus IC₅₀ >500 µM for acid ceramidase). This inhibition results in over 3-fold increase in endogenous ceramide in treated cells due to lack of breakdown of ceramide to sphingosine.

A synthetic analog of ceramide. Shown to selectively inhibit alkaline ceraminidase both in vitro and in HL-60 cells (IC₅₀ = 1-5 µM for alkaline ceramides versus IC₅₀ >500 µM for acid ceraminidase). This inhibition results in and over 3-fold increase in endogenous ceramide in treated cells due to a lack of breakdown of ceramide to sphingosine.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
Alkaline ceramidase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1-5 µM for alkaline ceramidase versus >500 µM for acid ceramidase

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Sonstige Hinweise

Bielawska, A., et al. 1996. J. Biol. Chem. 271, 12646.
Hannun, Y.A. 1996. Science274, 1855.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable