375217

2-Chlor-4,6-dimethoxy-1,3,5-triazin

97%

• Synonym(e): 2,4-Dimethoxy-6-chloro-1,3,5-triazine, 2,4-Dimethoxy-6-chloro-s-triazine, 2-Chloro-4,6-dimethoxy-1,3,5-triazine, 2-Chloro-4,6-dimethoxy-s-triazine, 4,6-Dimethoxy-2-chloro-s-triazine, 6-Chloro-2,4-dimethoxy-s-triazine, CDMT, Chlorodimethoxytriazine
• Empirische Formel (Hill-System): C₅H₆ClN₃O₂
• CAS-Nummer: 3140-73-6
• Molekulargewicht: 175.57
• Beilstein: 148988
• EG-Nummer: 221-541-0
• MDL-Nummer: MFCD00075607
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24863373
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Assay: 97%
• Form: solid
• mp (Schmelzpunkt): 71-74 °C (lit.)
• Funktionelle Gruppe: chloro
• SMILES String: COc1nc(Cl)nc(OC)n1
• InChI: 1S/C5H6ClN3O2/c1-10-4-7-3(6)8-5(9-4)11-2/h1-2H3
• InChIKey: GPIQOFWTZXXOOV-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

2-Chloro-4,6-dimethoxy-1,3,5-triazine is a stable, yet highly reactive, peptide coupling agent. It is reported as useful coupling reagent for the purification of peptides. Catalytic amide-forming reactions of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. Procedure for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported.

Anwendung

A stable, yet highly reactive, peptide coupling agent.

2-Chloro-4,6-dimethoxy-1,3,5-triazine may be used in the following studies:

• The specific labeling of streptavidin by the modular method for affinity labeling (MoAL).
• The preparation of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, via reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine.
• The preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts, via reaction with various tertiary amines.
• The synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, via coupling with N-methylmorpholine in THF.

Sicherheitshinweise

• Piktogramme: GHS05,GHS07,GHS09
• Signalwort: Danger
• H-Sätze: H314,H317,H411
• P-Sätze: P260 - P272 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Gefahreneinstufungen: Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
• Lagerklassenschlüssel: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves