198005

2-Chlor-1-methylpyridiniumiodid

97%

• Synonym(e): Mukaiyama reagent
• Empirische Formel (Hill-System): C₆H₇ClIN
• CAS-Nummer: 14338-32-0
• Molekulargewicht: 255.48
• Beilstein: 3572320
• EG-Nummer: 238-288-7
• MDL-Nummer: MFCD00011984
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24851856
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Assay: 97%
• mp (Schmelzpunkt): 200 °C (dec.) (lit.)
• Funktionelle Gruppe: chloro
• SMILES String: [I-].C[n+]1ccccc1Cl
• InChI: 1S/C6H7ClN.HI/c1-8-5-3-2-4-6(8)7;/h2-5H,1H3;1H/q+1;/p-1
• InChIKey: ABFPKTQEQNICFT-UHFFFAOYSA-M

Beschreibung

Allgemeine Beschreibung

2-Chloro-1-methylpyridinium iodide (Mukaiyama reagent), is a commonly used reagent in organic synthesis for the activation of the hydroxy group of alcohols and carboxylic acids. It is used to synthesize derivatives of esters, lactones, amides, lactams, and ketenes from the corresponding carboxylic acids. It is also used as an efficient coupling reagent in the synthesis of peptides because of its low toxicity, simple reaction conditions, and also less expensive than EDC.

Anwendung

2-Chloro-1-methylpyridinium iodide (CMPI) can be used as:

• A dehydrating agent for the conversion of various aldoximes to nitriles, and alcohols into alkyl thiocyanates.
• A cross-linking agent to fabricate biodegradable cross-linked hyaluronic acid film and gelatin membranes for biomedical applications.
• A condensing agent to synthesize various β-lactams from β-amino acids.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves