141186

Chlormethylpivalat

97%

• Synonym(e): Chlormethyl-pivalat, POM-Cl
• Lineare Formel: (CH₃)₃CCOOCH₂Cl
• CAS-Nummer: 18997-19-8
• Molekulargewicht: 150.60
• Beilstein: 1560838
• EG-Nummer: 242-735-1
• MDL-Nummer: MFCD00000884
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24848492
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Assay: 97%
• Form: liquid
• Brechungsindex: n20/D 1.417 (lit.)
• bp: 146-148 °C (lit.)
• Dichte: 1.045 g/mL at 25 °C (lit.)
• Funktionelle Gruppe: chloro; ester
• SMILES String: CC(C)(C)C(=O)OCCl
• InChI: 1S/C6H11ClO2/c1-6(2,3)5(8)9-4-7/h4H2,1-3H3
• InChIKey: GGRHYQCXXYLUTL-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Chloromethyl pivalate reacts with sodium salt of sulbactam to yield sulbactam pivoxil. It undergoes acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine (PMEA) to yield bis(pivaloyloxymethyl) PMEA.

Anwendung

Chloromethyl pivalate was used in the synthesis of pivaloyloxy methyl ester of ofloxacin as prodrug. It was used as the reagent during the synthesis of an isoindoline-annulated, tricyclic sultam library via microwave-assisted, continuous-flow organic synthesis.

Sicherheitshinweise

• Piktogramme: GHS02,GHS07
• Signalwort: Warning
• H-Sätze: H226,H302 + H312 + H332,H315,H319,H335
• P-Sätze: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): 104.0 °F - closed cup
• Flammpunkt (°C): 40 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter