SRE0053

Lysostaphin from Staphylococcus staphylolyticus

Suitable for manufacturing of diagnostic kits and reagents., lyophilized powder

• 동의어(들): Glycyl-glycine Endopeptidase
• CAS Number: 9011-93-2
• 효소 위원회 번호: 3.4.24.75 (BRENDA, IUBMB)
• MDL number: MFCD00131556
• UNSPSC 코드: 12352204
• NACRES: NA.32

속성

• 생물학적 소스: bacterial (Staphylococcus sp.)
• Quality Level: 400
• 양식: lyophilized powder
• 특이 활성도: ≥500 units/mg protein
• 분자량: 26,926 Da
• 구성: protein, 50-70% biuret
• 포장: pkg of (package size sold on basis of mg protein)
• 농도: 50—70% protein
• 적합성: suitable for microbiological tests
• 응용 분야: diagnostic assay manufacturing
• 배송 상태: wet ice
• 저장 온도: −20°C

설명

일반 설명

Lysostaphin is a glycylglycine endopeptidase. It is an important antibacterial enzyme.[1]

생화학적/생리학적 작용

Lysostaphin has the ability to cleave both viable and heat-killed S. aureus cells. It is one of the major antibacterial agents for the staphylococci.[2] Lysostaphin cleaves the cross-linking pentaglycine bridges in the cell walls of staphylococci. Thus it is considered as an antistaphylococcal therapeutic agent.[1]

Lysostaphin is a zinc endopeptidase with a molecular weight of approximately 25 kDa. Because lysostaphin cleaves the polyglycine cross-links in the peptidoglycan layer of the cell wall of Staphylococcus species it has been found useful for cell lysis and also as a potential anti-microbial therapeutic.
pH Optimum for activity: ~7.5

단위 정의

One unit will reduce the turbidity (A₆₂₀) of a suspension of Staphylococcus aureus cells from 0.250 to 0.125 in 10 min at pH7.5 at 37°C in a 6.0ml reaction mixture.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H334
• 예방조치 성명서: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable