SML2904
AGF347
≥98% (HPLC)
동의어(들):
(4-(4-(2-Amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl)-2-fluorobenzoyl)-L-glutamic acid, (S)-2-(4-(4-(2-Amino-4-oxo-3H-pyrrolo[3,2-d]pyrimidin-5(4H)-yl)butyl)-2-fluorobenzamido)pentanedioic acid, N-[4-[4-(2-Amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]-L-glutamic acid
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모든 사진(1)
크기 선택
보기 변경
5 MG
₩225,229
25 MG
₩723,898
About This Item
실험식(Hill 표기법):
C22H24FN5O6
CAS Number:
Molecular Weight:
473.45
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 2 mg/L, clear
저장 온도
2-8°C
SMILES string
O=C(CC[C@H](NC(C1=CC=C(C=C1F)CCCCN2C=CC(N=C(N3)N)=C2C3=O)=O)C(O)=O)O
생화학적/생리학적 작용
AGF347 is a potent inhibitor of serine hydroxymethyltransferase 2 (SHMT2) that inhibits mitochondrial C1 metabolism. It also inhibits cytosolic C1 targets such as SHMT1, GARFTase, and AICARFTase. AGF347 inhibits de novo purine biosynthesis. AGF347 exhibits potent broad spectrum in vitro and in vivo antitumor efficacy.
potent inhibitor of serine hydroxymethyltransferase 2 (SHMT2)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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시험 성적서(COA)
Lot/Batch Number
Aamod S Dekhne et al.
Molecular cancer therapeutics, 18(10), 1787-1799 (2019-07-11)
Folate-dependent one-carbon (C1) metabolism is compartmentalized into the mitochondria and cytosol and supports cell growth through nucleotide and amino acid biosynthesis. Mitochondrial C1 metabolism, including serine hydroxymethyltransferase (SHMT) 2, provides glycine, NAD(P)H, ATP, and C1 units for cytosolic biosynthetic reactions
Aamod S Dekhne et al.
Molecular pharmacology, 97(1), 9-22 (2019-11-11)
Folate-dependent one-carbon (C1) metabolism is compartmentalized in the mitochondria and cytosol and is a source of critical metabolites for proliferating tumors. Mitochondrial C1 metabolism including serine hydroxymethyltransferase 2 (SHMT2) generates glycine for de novo purine nucleotide and glutathione biosynthesis and
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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