19176

DL-Buthionine-sulfoximine

≥99.0% (TLC)

• 동의어(들): DL-Buthionine (S,R)-sulfoximine, BSO, Buthionine sulfoximine, Butionine sulfoximine
• 실험식(Hill 표기법): C₈H₁₈N₂O₃S
• CAS Number: 5072-26-4
• Molecular Weight: 222.31
• Beilstein: 2367136
• MDL number: MFCD00070309
• UNSPSC 코드: 12352202
• PubChem Substance ID: 57647786
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• 분석: ≥99.0% (TLC)
• 양식: powder or crystals
• mp: 215 °C
• solubility: H₂O: 50 mg/mL, clear to almost clear, colorless
• 저장 온도: 2-8°C
• SMILES string: CCCCS(=N)(=O)CCC(N)C(O)=O
• InChI: 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
• InChI key: KJQFBVYMGADDTQ-UHFFFAOYSA-N

설명

애플리케이션

DL-Buthionine-sulfoximine is suitable for use to:

• examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells[1]
• investigate the effect of BSO on development of bovine embryos[2]
• inhibit GSH in several studies[3][4]
• investigate the effect of GSH synthesis on oocyte maturation[5]

It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH[6]

생화학적/생리학적 작용

DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS.[7] It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).[8]

기타 정보

Depletes glutathionine in isolated cells[9][10]

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves