SML1891

PK11007

≥98% (HPLC)

• 동의어(들): 5-Chloro-2-(methylsulfonyl)-4-pyrimidinecarboxylic acid
• 실험식(Hill 표기법): C₆H₅ClN₂O₄S
• CAS Number: 38275-34-2
• Molecular Weight: 236.63
• MDL number: MFCD00507244
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: H₂O: 10 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: [S](=O)(=O)(C)c1nc(c(cn1)Cl)C(=O)O
• InChI: 1S/C6H5ClN2O4S/c1-14(12,13)6-8-2-3(7)4(9-6)5(10)11/h2H,1H3,(H,10,11)
• InChI key: WZUPWJVRWIVWEF-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

PK11007 is a thiol-reactive anticancer agent that stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding.

PK11007 is a thiol-reactive anticancer agent that stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding. Additionally independently from p53, PK11007 impairs reactive oxygen species (ROS) detoxification in a number of mutant p53 cancer cells. PK11007 exhibits anticancer activity in number of cancer cell lines while shoving low cytotoxicity toward normal cells.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319
• 예방조치 성명서: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable