D3900

Desipramine hydrochloride

≥98% (TLC), powder, tricyclic antidepressant

• 실험식(Hill 표기법): C₁₈H₂₂N₂ · HCl
• CAS Number: 58-28-6
• Molecular Weight: 302.84
• EC Number: 200-373-1
• MDL number: MFCD00058108
• UNSPSC 코드: 12352116
• PubChem Substance ID: 24278094
• NACRES: NA.77

속성

• 제품명: Desipramine hydrochloride, ≥98% (TLC), powder
• Quality Level: 100
• 분석: ≥98% (TLC)
• 양식: powder
• 색상: white to off-white
• solubility: H₂O: 50 mg/mL
• 주관자: Sanofi Aventis
• 저장 온도: 2-8°C
• SMILES string: Cl[H].CNCCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
• InChI key: XAEWZDYWZHIUCT-UHFFFAOYSA-N
• 유전자 정보: human ... SLC6A2(6530)

설명

일반 설명

Desipramine, a metabolite of imipramine and iofepramine is an active tricyclic antidepressant.[1]

애플리케이션

Desipramine hydrochloride has been used:

• to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons[2]
• to protect unselective damage to the noradrenergic system[3]
• as a norepinephrine re-uptake inhibitor to treat rats for lesioning[4]

생화학적/생리학적 작용

Desipramine is used to treat depression. It is also used to manage enuresis in children.[1] Desipramine helps to eliminate the pain triggered by diabetic neuropathy.[5]

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (K_i = 4 nM) than the serotonin transporter (K_i = 61 nM).

특징 및 장점

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

주의사항

Hygroscopic

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H315,H317,H319,H334,H335
• 예방조치 성명서: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves