T2877

3,3′,5-Triiodo-L-thyronine

≥95% (HPLC), powder

• 동의어(들): O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T₃
• 실험식(Hill 표기법): C₁₅H₁₂I₃NO₄
• CAS Number: 6893-02-3
• Molecular Weight: 650.97
• Beilstein: 2710227
• EC Number: 229-999-3
• MDL number: MFCD00002593
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24900088
• NACRES: NA.32

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 무균: non-sterile
• 분석: ≥95% (HPLC)
• 형태: powder
• 광학 활성: [α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2
• 기술: transfection: suitable
• mp: 234-238 °C (lit.)
• solubility: 4 M NH₄OH in methanol: 5 mg/mL, clear to very slightly hazy, colorless to light yellow
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
• InChI: 1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
• InChI key: AUYYCJSJGJYCDS-LBPRGKRZSA-N
• 유전자 정보: human ... THRA(7067) , THRB(7068) ; rat ... Thra(81812) , Thrb(24831)

설명

애플리케이션

3,3′,5-Triiodo-L-thyronine can be used for Insulin-like growth factor I assays performed by using a double antibody radioimmunoassay. The product can also be used for in vitro transfection of 293T cells.

생화학적/생리학적 작용

3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine enhances mood and neuropsychological function. The product also positively regulates the hepatic FGF21 expression and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation. Additionally, the product facilitates the normal body growth in children and is pivotal for central nervous system maturation in foetus.

제조 메모

3,3′,5-Triiodo-L-thyronine dissolves in 4M NH4OH in MeOH at 5 mg/ml to yield a colorless to light yellow, clear to very slightly hazy solution.

기타 정보

This product has not been tested for cell culture. A sterile version is offered that is suitable for cell culture. The T5516 is a sterile preparation that is cell culture tested. Please review the product page for product T2877

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H372
• 예방조치 성명서: P260 - P264 - P270 - P314 - P501
• Hazard Classifications: STOT RE 1
• 표적 기관: Thyroid,Cardio-vascular system,Kidney
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves