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Merck
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주요 문서

B7283

Sigma-Aldrich

Benserazide hydrochloride

≥98% (HPLC), solid, L-aromatic amino acid decarboxylase inhibitor

동의어(들):

DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride

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크기 선택

1 G
₩242,788
5 G
₩659,243

₩242,788


예상 입고일2025년 2월 17일세부사항


벌크 견적 요청

크기 선택

보기 변경
1 G
₩242,788
5 G
₩659,243

About This Item

실험식(Hill 표기법):
C10H15N3O5 · HCl
CAS Number:
Molecular Weight:
293.70
EC Number:
MDL number:
UNSPSC 코드:
12352125
PubChem Substance ID:
NACRES:
NA.77

₩242,788


예상 입고일2025년 2월 17일세부사항


벌크 견적 요청

제품명

Benserazide hydrochloride, ≥98% (HPLC), solid

생물학적 소스

synthetic

Quality Level

분석

≥98% (HPLC)

양식

solid

solubility

H2O: 10 mg/mL

주관자

Roche

저장 온도

room temp

SMILES string

Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O

InChI

1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H

InChI key

ULFCBIUXQQYDEI-UHFFFAOYSA-N

유전자 정보

human ... DDC(1644)

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일반 설명

Benserazide is a peripheral decarboxylase inhibitor.[1]

애플리케이션

Benserazide has been used:
  • to inhibit dopa-decarboxylase[2]
  • to induce dyskinesia[3]
  • to test on purified bacterial TDCs to assess the extent to which it could affect bacterial decarboxylases[4]
  • as a peripheral dopa decarboxylase inhibitor to treat mice[5]

생화학적/생리학적 작용

Benserazide can block HK2 enzymatic activity in vitro. It is used along with levodopa to treat Parkinson′s disease. [6]
Inhibitor of L-aromatic amino acid decarboxylase.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Restoration of the dopamine transporter through cell therapy improves dyskinesia in a rat model of Parkinson?s Disease
Tomas D, et al.
PLoS ONE, 11(4), e0153424-e0153424 (2016)
Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine
Tillerson JL, et al.
Experimental Neurology, 178, 80-90 (2002)
24 - Extrapyramidal movement disorders and spasticity
Waller DG, et al.
Medical Microbiology, 325-336 (2018)
Developmental and evolutionary basis for drought tolerance of the Anopheles gambiae embryo
Goltsev Y, et al.
Developmental Biology, 330(2), 462-470 (2009)
Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2
Li W, et al.
Journal of Experimental & Clinical Cancer Research, 36(1), 58-58 (2017)

문서

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

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DISCOVER Bioactive Small Molecules for Neuroscience

질문

  1. What is the recommended storage temperature for Benserazide hydrochloride (Product B7283) after the drug is suspended in water?

    1 답변
    1. Benserazide hydrochloride is soluble in water and should be dissolved in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidants. The solutions decompose on exposure to light and air. Benserazide HCl is a tan, photosensitive solid and should be stored tightly sealed at -4°C, protected from exposure to light. It is not recommended to store the aqueous solution for more than one day.

      Additionally, the product is subject to oxidation, and it is advisable to make solutions fresh daily. The product should be stored, as supplied, at room temperature for up to 1 year, and it should be protected from light.

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