S7076

SB 202190 monohydrochloride hydrate

≥98% (HPLC), solid, p38 MAP kinase inhibitor

• 동의어(들): 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole monohydrochloride hydrate, 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride hydrate
• 실험식(Hill 표기법): C₂₀H₁₄FN₃O · HCl · xH₂O
• CAS Number: 350228-36-3
• Molecular Weight: 367.80 (anhydrous basis)
• MDL number: MFCD17215958
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329824576
• NACRES: NA.77

속성

• 제품명: SB 202190 monohydrochloride hydrate, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 저장 조건: desiccated
• 색상: white to beige
• solubility: DMSO: ≥12 mg/mL
• 주관자: GlaxoSmithKline
• 저장 온도: 2-8°C
• SMILES string: O.Cl.Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
• InChI: 1S/C20H14FN3O.ClH.H2O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15;;/h1-12,25H,(H,23,24);1H;1H2
• InChI key: CZZOICWZVYZUNP-UHFFFAOYSA-N

설명

애플리케이션

SB 202190 may be used to inhibit p38-mediated cell signaling.

SB 202190 monohydrochloride hydrate has been used as a component of human prostate culture medium[1] and organoid culture medium[2] It has also been used as p38 mitogen activated protein kinase (MAPK) inhibitor in colon cancer cells.[3]

생화학적/생리학적 작용

SB 202190 binds within the ATP pocket of p38 kinase and inhibits the p38α and β isoforms.

SB 202190 is a highly selective, potent, and cell-permeable inhibitor of p38 MAP kinase.

SB 202190 monohydrochloride hydrate mediates the phosphorylation of serine in the mutant p53 protein and modulates cell adhesion and prevents cell proliferation in breast cancer cell lines.[4]

특징 및 장점

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable