G9145

[Leu¹⁵]-Gastrin I human

≥95% (HPLC)

• 동의어(들): [Leu¹⁵]-HG-17, LHG-17, [15-Leucine]-Gastrin I, human heptadecapeptide, [18-Pyroglutamic acid, 32-leucine]-Big gastrin I-(18-34)-peptide amide, human, [Leu¹⁵]-Gastrin I, human, [Leucine¹⁵]-Gastrin I heptadecapeptide, [Leucine¹⁵]-Little gastrin I
• 실험식(Hill 표기법): C₉₈H₁₂₆N₂₀O₃₁
• CAS Number: 39024-57-2
• Molecular Weight: 2080.16
• Beilstein: 5227423
• EC Number: 254-250-2
• MDL number: MFCD00076502
• UNSPSC 코드: 12352209
• PubChem Substance ID: 24895364
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 200
• 분석: ≥95% (HPLC)
• 양식: powder
• 기술: cell culture | mammalian: suitable
• UniProt 수납 번호: P01350
• 저장 온도: −20°C
• SMILES string: CC(C)CC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C3CCCN3C(=O)CNC(=O)C4CCC(=O)N4)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(C)C(=O)NC(Cc5ccc(O)cc5)C(=O)NCC(=O)NC(Cc6c[nH]c7ccccc67)C(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc8ccccc8)C(N)=O
• InChI: 1S/C98H126N20O31/c1-49(2)38-68(115-96(147)72(43-55-46-101-60-19-12-10-17-58(55)60)117-98(149)74-20-13-37-118(74)77(122)48-103-86(137)61-25-31-75(120)105-61)93(144)111-66(30-36-82(131)132)92(143)110-65(29-35-81(129)130)91(142)109-64(28-34-80(127)128)90(141)108-63(27-33-79(125)126)89(140)107-62(26-32-78(123)124)88(139)104-51(5)85(136)113-70(41-53-21-23-56(119)24-22-53)87(138)102-47-76(121)106-71(42-54-45-100-59-18-11-9-16-57(54)59)95(146)114-69(39-50(3)4)94(145)116-73(44-83(133)134)97(148)112-67(84(99)135)40-52-14-7-6-8-15-52/h6-12,14-19,21-24,45-46,49-51,61-74,100-101,119H,13,20,25-44,47-48H2,1-5H3,(H2,99,135)(H,102,138)(H,103,137)(H,104,139)(H,105,120)(H,106,121)(H,107,140)(H,108,141)(H,109,142)(H,110,143)(H,111,144)(H,112,148)(H,113,136)(H,114,146)(H,115,147)(H,116,145)(H,117,149)(H,123,124)(H,125,126)(H,127,128)(H,129,130)(H,131,132)(H,133,134)
• InChI key: CMVMLPDUAGUTOC-UHFFFAOYSA-N
• 유전자 정보: human ... GAST(2520)

설명

Amino Acid Sequence

Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2

일반 설명

GAST gene encodes for the protein [Leu15]-Gastrin I in human. In human chromosome, the gene GAST is localized on 17q21.2.[1] G cells in the stomach antrum produces the precursor of [Leu15]-Gastrin I, progastrin.[1] Progastrin undergoes cleavage and processing to yield gastrin, which is trophic for the entire gastrointestinal epithelium. Gastrin is essential for the growth of the digestive system and stimulates the production of gastric acid by parietal cells. Gastrin exerts its function through G-protein-coupled receptor called the cholecystokinin (CCK) or CCK-B receptor (CCK-BR).[2] Gastrin release is stimulated by food, especially protein diet and is inhibited by very low pH. Atrophic gastritis, a Helicobacter pylori infection and long-term administration of proton pump inhibitors infection may cause overexpression of gastrin. Gastric adenocarcinoma show high levels of gastrin.[1]

애플리케이션

Gastrin has been used:

• as a medium supplement establish enteroid cultures[3]
• as a supplement to standard Dulbecco′s Modified Eagle Medium (DMEM) culture medium,[4][5] human minigut medium[6] to establish the growth of crypts.

생화학적/생리학적 작용

Gastrin I analog with full biological activity and improved stability in aqueous solutions. Leu¹⁵ replaces Met¹⁵, that is readily oxidized resulting in loss of biological activity.

기타 정보

Lyophilized from 0.1% TFA in H2O

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)