72340

Nicotinamide

≥99.5% (HPLC)

• 동의어(들): Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B₃, Vitamin PP
• 실험식(Hill 표기법): C₆H₆N₂O
• CAS Number: 98-92-0
• Molecular Weight: 122.12
• Beilstein: 383619
• EC Number: 202-713-4
• MDL number: MFCD00006395
• UNSPSC 코드: 12352205
• PubChem Substance ID: 57652413
• NACRES: NA.79

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: ≥99.5% (HPLC)
• 양식: powder or crystals
• 무기 잔류물: ≤0.2%
• 손실: ≤0.2% loss on drying, 20 °C (HV)
• 색상: colorless to white
• mp: 128-131 °C (lit.); 128-131 °C
• 음이온 미량물: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤150 mg/kg
• 양이온 미량물: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• 응용 분야: cell analysis
• SMILES string: NC(=O)c1cccnc1
• InChI: 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
• InChI key: DFPAKSUCGFBDDF-UHFFFAOYSA-N
• 유전자 정보: human ... PARP1(142) , SIRT2(22933)

설명

일반 설명

Nicotinamide, a form of vitamin B3, is a building block of coenzymes NAD and NADP. Researchers consider it an important signaling molecule, and essential for cell metabolism studies. It has been used in multiple applications and research areas, namely cancer and viral research.

애플리케이션

Nicotinamide has been used:

• to study its effect on the expression of sirtuin 1[1]
• in nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phopshate (NAD+/NADH) cycling assay[2]
• in cell lysis buffer, to serve as a sirtuin 1 inhibitor in order to study its role in resveratrol (RSV)-stimulated hepatitis B virus replication[3]

생화학적/생리학적 작용

Nicotinamide (Niacinamide) (Nam) is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). Nicotinamide may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule.

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

The coenzymes NAD and NADP take part in energy yielding metabolism and mediate several oxidation-reduction reactions. NAD hydrolyses to form nicotinamide, which is then transported to other tissues.[4] Hydrolysis of nicotinamide yields nicotinic acid through salvage pathway.[5]

기타 정보

Coenzymes and Cofactors, vol. 2: Pyridine Nucleotide Coenzymes[6][7]

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H319
• 예방조치 성명서: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): 302.0 °F - closed cup
• Flash Point (°C): 150 °C - closed cup
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves