This product is a mixture of Oleic acid and Cyclodextrin. Each gram of powder will include a minimum of 28 mg Oleic acid. The product is sold by Oleic acid content. At the minimum Oleic acid content, the 10 mg package size would contain a total of 357 mg of powder. The Oleic acid content is lot specific. Please see the link below to review a sample or lot specific Certificate of Analysis:
https://www.sigmaaldrich.com/product/sigma/o1257#product-documentation
추천 제품
생물학적 소스
synthetic (organic)
Quality Level
제품 라인
BioReagent
양식
powder
구성
Oleic acid, ~30 mg/g (balance methyl-β-cyclodextrin)
기술
cell culture | mammalian: suitable
solubility
H2O: 50 mg/mL, clear to slightly hazy
저장 온도
−20°C
SMILES string
CCCCCCCC\C=C/CCCCCCCC(O)=O
InChI
1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-
InChI key
ZQPPMHVWECSIRJ-KTKRTIGZSA-N
유전자 정보
human ... SOAT1(6646) , SOAT2(8435)
애플리케이션
Oleic Acid-Water Soluble has been used:
- to prepare the FFAs (free fatty acids) mixture for cell treatment[1]
- to investigate its effect on the solute carrier family 2 member 4 (SLC2A4)/GLUT4 expression in L6 muscle cells and as potential transcriptional regulators[2]
- in the preparation of fatting media for the induction of in vitro steatosis in primary human hepatocytes[3]
기타 정보
Methyl-β-cylodextran binding improves the solubility and delivery of Oleic acid in culture media.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
A20 attenuates FFAs-induced lipid accumulation in nonalcoholic steatohepatitis
Ai L, et al.
International Journal of Biological Sciences, 11(12), 1436-1436 (2015)
Shuo Li et al.
International journal of biological sciences, 17(15), 4165-4175 (2021-11-23)
Background: Inflammation and apoptosis play a crucial role in the progression of nonalcoholic steatohepatitis (NASH). Suppressor of cytokine signaling 2 (SOCS2) is one of classic negative regulators of cytokine signaling, which has recently been described as anti-inflammatory mediators. However, the
Oleic and linoleic fatty acids downregulate Slc2a4/GLUT4 expression via NFKB and SREBP1 in skeletal muscle cells
Poletto A C, et al.
Molecular and Cellular Endocrinology, 401(12), 65-72 (2015)
Pu Sun et al.
Journal for immunotherapy of cancer, 9(8) (2021-08-11)
The phosphatidylinositol 3-kinase (PI3K) is frequently hyperactivated in cancer and plays important roles in both malignant and immune cells. The effect of PI3Kα inhibitors on the tumor microenvironment (TME) remains largely unknown. Here, we investigated the modulation of the TME
Su-Yi Tsai et al.
Cardiovascular research, 116(3), 658-670 (2019-06-08)
Human embryonic stem cells (hESCs) can be used to generate scalable numbers of cardiomyocytes (CMs) for studying cardiac biology, disease modelling, drug screens, and potentially for regenerative therapies. A fluorescence-based reporter line will significantly enhance our capacities to visualize the
문서
Supplement cell culture systems with fatty acids for biomanufacturing heterologous proteins like monoclonal antibodies.
How the unsaturated fatty acid, oleic acid and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies.
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Could you please clarify whether the entire 10mg of the compound is oleic acid, or does the 10mg compound actually contain 377ug (37.7mg/g * 10mg) of oleic acid, considering the specified concentration?
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