L6295
Lomerizine dihydrochloride
≥98% (HPLC), powder
동의어(들):
1-[Bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride
로그인조직 및 계약 가격 보기
크기 선택
10 MG
₩167,272
50 MG
₩677,005
모든 사진(1)
크기 선택
보기 변경
10 MG
₩167,272
50 MG
₩677,005
About This Item
실험식(Hill 표기법):
C27H30F2N2O3·2HCl
CAS Number:
Molecular Weight:
541.46
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.25
추천 제품
분석
≥98% (HPLC)
양식
powder
색상
white to tan
solubility
DMSO: ≥30 mg/mL
저장 온도
2-8°C
SMILES string
Cl.Cl.COc1ccc(CN2CCN(CC2)C(c3ccc(F)cc3)c4ccc(F)cc4)c(OC)c1OC
InChI
1S/C27H30F2N2O3.2ClH/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20;;/h4-13,25H,14-18H2,1-3H3;2*1H
InChI key
LOGVKVSFYBBUAJ-UHFFFAOYSA-N
생화학적/생리학적 작용
Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator.
Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator. It is one of the most selective calcium channel blockers for the CNS and cerebral arteries. It has been reported to inhibit both T-type and L-type Ca2+ currents in rat hippocampal CA1 pyramidal neurons, to prevent glutamate-induced neurotoxicity in rat hippocampal primary cell cultures, and to exhibit protective effects in animal models of migraine, ischemia and hypoxia. In Japan, lomerizine has been used as the first-line prophylactic drug for migraines.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Toshiki Mizuno et al.
Clinical neuropharmacology, 32(2), 113-116 (2009-06-11)
A 64-year-old woman was admitted to our hospital for recurrent stroke and cognitive impairment and was diagnosed with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Iodine-123 iodoamphetamine single photon emission computed tomography showed hypoperfusion in the whole
Bian-Sheng Ji et al.
Die Pharmazie, 65(7), 515-519 (2010-07-29)
P-Glycoprotein, a 170-180 kDa membrane glycoprotein that mediates multidrug resistance, hydrolyses ATP to efflux a broad spectrum of hydrophobic agents. To observe the interaction of a P-gp reversal agent with P-gp ATPase activity should provide further insights into the mechanisms
Secondary degeneration of the optic nerve following partial transection: the benefits of lomerizine.
Melinda Fitzgerald et al.
Experimental neurology, 216(1), 219-230 (2009-01-03)
Secondary degeneration is a form of 'bystander' damage that can affect neural tissue both nearby and remote from an initial injury. Partial optic nerve transection is an excellent model in which to unequivocally differentiate events occurring during secondary degeneration from
Yasuhiro Tamaki et al.
Investigative ophthalmology & visual science, 44(11), 4864-4871 (2003-10-28)
To investigate the effects of lomerizine, a Ca2+ antagonist, on the ocular tissue circulation in rabbits and on the circulation in the optic nerve head (ONH) and choroid in healthy volunteers. Lomerizine (0.1 [n=10] or 0.3 [n=11] mg/kg) or vehicle
Shinichi Iwasaki et al.
Acta oto-laryngologica. Supplementum, (559)(559), 45-49 (2008-04-12)
Lomerizine, a calcium channel blocker, may be effective as a treatment for migraine-associated vertigo (MAV). Objective. To determine the clinical characteristics of patients with MAV in Japan and the effectiveness of lomerizine. This was a retrospective chart review carried out
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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