This product may be stored at room temperature in the powdered format. The solution stability of this material has not been determined. However, various external sources indicate that prepared solutions are stable up to 1 month when stored tightly sealed in aliquots at -20°C. This information has not been validated.
M5441
Mibefradil dihydrochloride hydrate
≥98% (HPLC), powder, T-type Ca²⁺ channel blocker
동의어(들):
(1S,2S)-2-[2[[3-(2-Benzimidazolyl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate dihydrochloride hydrate, Ro 40-5967 hydrate
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5 MG
₩337,386
25 MG
₩945,574
About This Item
실험식(Hill 표기법):
C29H38FN3O3 · 2HCl · xH2O
CAS Number:
Molecular Weight:
568.55 (anhydrous basis)
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
제품명
Mibefradil dihydrochloride hydrate, ≥98% (HPLC), powder
분석
≥98% (HPLC)
양식
powder
저장 조건
desiccated
색상
white
solubility
H2O: soluble >20 mg/mL
absolute ethanol: insoluble
주관자
Roche
SMILES string
O.Cl.Cl.COCC(=O)O[C@]3(CCN(C)CCCc1nc2ccccc2[nH]1)CCc4cc(F)ccc4[C@@H]3C(C)C
InChI
1S/C29H38FN3O3.2ClH.H2O/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26;;;/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32);2*1H;1H2/t28-,29-;;;/m0.../s1
InChI key
IZSWBBGKLWFDOC-YKXHUFBBSA-N
애플리케이션
생화학적/생리학적 작용
Mibefradil is a tetralol derivative and nondihydropyridine calcium channel blocker. It blocks long-type (L-type) calcium channels.[3][4] It blocks mildly the Purkinje-type (P-type) calcium channels in Purkinje neurons.[5]
Ro 40-5967 is a T-type Ca2+ channel blocker; antihypertensive.
특징 및 장점
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Mibefradil block of cloned T-type calcium channels
Martin R L, et al.
Journal of Pharmacology and Experimental Therapeutics, 295(1), 302-308 (2000)
Mibefradil inhibition of T-type calcium channels in cerebellar purkinje neurons
McDonough S I and Bean B P
Molecular Pharmacology, 54(6), 1080-1087 (1998)
Bobbi-Jo Lowie et al.
American journal of physiology. Gastrointestinal and liver physiology, 301(5), G835-G845 (2011-08-13)
Interstitial cells of Cajal associated with the myenteric plexus (ICC-MP) are pacemaker cells of the small intestine, producing the characteristic omnipresent electrical slow waves, which orchestrate peristaltic motor activity and are associated with rhythmic intracellular calcium oscillations. Our objective was
Calcium channels are involved in EphB/ephrinB reverse signaling-induced apoptosis in a rat chronic ocular hypertension model
Dong L, et al.
Molecular Medicine Reports, 17(2), 2465-2471 (2018)
Cornelia Kopp-Scheinpflug et al.
Neuron, 71(5), 911-925 (2011-09-10)
Offset responses upon termination of a stimulus are crucial for perceptual grouping and gap detection. These gaps are key features of vocal communication, but an ionic mechanism capable of generating fast offsets from auditory stimuli has proven elusive. Offset firing
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