P0018

Pomalidomide

≥98% (HPLC), powder, HbF inducer

• 동의어(들): 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide, 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, Actimid, CC-4047, IMiD 3
• 실험식(Hill 표기법): C₁₃H₁₁N₃O₄
• CAS Number: 19171-19-8
• Molecular Weight: 273.24
• MDL number: MFCD12756407
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329819974
• NACRES: NA.77

속성

• product name: Pomalidomide, ≥98% (HPLC)
• ligand: pomalidomide
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 반응 적합성: reagent type: ligand
• 색상: yellow
• solubility: DMSO: ≥14 mg/mL
• 저장 온도: 2-8°C
• SMILES string: Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
• InChI: 1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
• InChI key: UVSMNLNDYGZFPF-UHFFFAOYSA-N
• 유전자 정보: human ... CRBN(51185) , CUL4A(8451) , DDB1(1642) , RBX1(9978)

설명

애플리케이션

Pomalidomide has been used:

• to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides
• for apoptosis studies and intracellular calcium analysis
• as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells

생화학적/생리학적 작용

Pomalidomide is an effective fetal hemoglobin (HbF) inducer that downregulates the key &#947-globin repressors, SRY-box transcription factor 6 (SOX6), and BAF chromatin remodeling complex subunit (BCL11A).

Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog.

특징 및 장점

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H360D
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable