178278

Apigenin

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM).

• 동의어(들): Apigenin, 4ʹ,5,7-Trihydroxyflavone
• 실험식(Hill 표기법): C₁₅H₁₀O₅
• CAS Number: 520-36-5
• Molecular Weight: 270.24
• MDL number: MFCD00006831
• UNSPSC 코드: 12352212
• NACRES: NA.77

속성

• Quality Level: 100
• 설명: Merck USA index - 14, 730
• 분석: ≥98% (HPLC)
• 양식: crystalline solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: yellow
• solubility: hot ethanol: 1 mg/mL; DMSO: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: [o]1c2c([c](cc1c3ccc(cc3)O)=O)c(cc(c2)O)O
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
• InChI key: KZNIFHPLKGYRTM-UHFFFAOYSA-N

설명

일반 설명

A plant flavonoid that reverses the transformed phenotypes of various ras-transformed cells, apparently due to inhibition of mitogen activated protein (MAP) kinase-associated signal transduction pathways. Treatment of v-H-ras-transformed NIH 3T3 cells with apigenin (12.5 µM) has been shown to induce dephosphorylation of p44^mapk and reduction in MAP kinase activity. Has also been reported to inhibit the proliferation of malignant tumor cells by G₂/M arrest and to induce morphological differentiation.

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM). This finding has been attributed to the inhibition of MAP kinase activity. Inhibits the proliferation of malignant tumor cells by G₂/M arrest and induces morphological differentiation.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
MAP kinase

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Irritant (B)

재구성

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C.

기타 정보

Kuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun.212, 767.
Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
Kuo, M.L., et al. 1994. Cancer Lett.87, 91.
Sato, F., et al. 1994. Biochem. Biophys. Res. Commun.204, 578.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3