L0517
Leukotriene B4
~100 μg/mL in ethanol, ≥97%
동의어(들):
[5S,12R]-Dihydroxy-[6Z,8E,10E,14Z]-eicosatetraenoic acid
로그인조직 및 계약 가격 보기
모든 사진(2)
크기 선택
보기 변경
10 μG
₩671,829
25 μG
₩848,642
50 μG
₩1,421,812
About This Item
실험식(Hill 표기법):
C20H32O4
CAS Number:
Molecular Weight:
336.47
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥97%
양식
liquid
농도
~100 μg/mL in ethanol
배송 상태
dry ice
저장 온도
−20°C
SMILES string
CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
InChI
1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
InChI key
VNYSSYRCGWBHLG-AMOLWHMGSA-N
유전자 정보
human ... LTB4R(1241)
rat ... Ltb4r(59264)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
생화학적/생리학적 작용
Proinflammatory agent. Stimulates c-Fos and c-Jun proto-oncogene transcription in human monocytes. Stimulates chemotaxis, aggregation, and degranulation of polymorphonuclear leukocytes.
특징 및 장점
This compound is featured on the Leukotriene Receptors and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
포장
Data sheet which accompanies each product includes special handling instructions. Except where noted, method for hydrolysis of methyl esters is also described.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Flash Point (°F)
57.2 °F - closed cup
Flash Point (°C)
14.0 °C - closed cup
이미 열람한 고객
L Iversen et al.
The Journal of investigative dermatology, 100(3), 293-298 (1993-03-01)
In the present study, keratinocytes were coincubated with human neutrophils to determine whether or not an increase in leukotriene B4 formation can occur. Human keratinocytes used were cultured in serum-free, low-calcium medium, whereas neutrophils were purified from heparinized venous blood.
Vincenzo Quagliariello et al.
Journal of personalized medicine, 10(4) (2020-10-23)
Several strategies based on immune checkpoint inhibitors (ICIs) have been developed for cancer therapy, opening to advantages in cancer outcomes. However, several ICI-induced side effects have emerged in these patients, especially a rare but clinically significant cardiotoxicity with high rate
H E Claesson et al.
International journal of immunopharmacology, 14(3), 441-449 (1992-04-01)
Leukotriene (LT) B4 is a biologically active molecule derived from arachidonic acid via the 5-lipoxygenase pathway. It mediates certain inflammatory and immunological reactions. The role of LTB4 in the immune system has been questioned since lymphocytes have been regarded to
Lloyd Tanner et al.
Journal of innate immunity, 12(3), 203-225 (2019-09-19)
Chronic obstructive pulmonary disease (COPD) affects the lives of an ever-growing number of people worldwide. The lack of understanding surrounding the pathophysiology of the disease and its progression has led to COPD becoming the third leading cause of death worldwide.
Preeti Subramanian et al.
Investigative ophthalmology & visual science, 57(11), 4581-4588 (2016-09-17)
5-Lipoxygenase (5-LOX) oxygenates arachidonic acid to form 5-hydroperoxyeicosatetraenoic acid, which is further converted into biologically detrimental leukotrienes, such as leukotriene B4 (LTB4). The RPE and retina express the PNPLA2 gene for pigment epithelium-derived factor receptor (PEDF-R), a lipase involved in
문서
지질 신호전달 연구를 위한 생체 활성 저분자
Discover Bioactive Small Molecules for Lipid Signaling Research
활성 필터
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