K1751

Ketoprofen

≥98% (TLC), powder, non-steroidal anti-inflammatory compound

• 동의어(들): 2-(3-Benzoylphenyl)propionic acid
• 실험식(Hill 표기법): C₁₆H₁₄O₃
• CAS Number: 22071-15-4
• Molecular Weight: 254.28
• EC Number: 244-759-8
• MDL number: MFCD00055790
• UNSPSC 코드: 12352200
• PubChem Substance ID: 57654315
• NACRES: NA.77

속성

• 제품명: Ketoprofen, ≥98% (TLC)
• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: ≥98% (TLC)
• 양식: powder
• solubility: ethanol: 50 mg/mL, clear, colorless to yellow
• 주관자: Bayer
• SMILES string: CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2
• InChI: 1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
• InChI key: DKYWVDODHFEZIM-UHFFFAOYSA-N
• 유전자 정보: human ... ALB(213) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743)

설명

일반 설명

Ketoprofen belongs to the class of 2-arylpropionic acid.[1]

애플리케이션

Ketoprofen has been used:

• as sample to analyse the effects of long storage period by chromatographic and microscopic techniques[2]
• as a nonselective COX inhibitor to inject subcutaneously in rats to study its effect on stress/methamphetamine hydrochloride-induced changes in occludin, claudin-5 and COX-2 protein immunoreactivity, truncation of β-dystroglycan, brain water content and fluorescein isothiocyanate-dextran extravasation[3]
• in phosphate buffer to study its ability to inhibit heat-induced denaturation of albumin[4]

생화학적/생리학적 작용

It serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis.[1] It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase.[5]

Non-steroidal anti-inflammatory compound that is selective for COX-1.

특징 및 장점

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS06,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H301,H315,H319,H400
• 예방조치 성명서: P264 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges