Immunoglobulins (Igs) belongs to the immunoglobulin super-family. There are five different types of Immunoglobulins. Each immunoglobin has two heavy (H) and two light (L) chains, held together by disulphide linkages. Each light chain comprises of one variable N-terminal region and a constant C-terminal region. Heavy chain has one variable N-terminal region and three or four constant (CH1-CH4) C-terminal regions. The four classes of IgG can be IgG1, IgG2, IgG3, and IgG4.
애플리케이션
Anti-Human IgG (whole molecule) antibody produced in rabbit has been used in enzyme linked immunosorbent assay.
생화학적/생리학적 작용
IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.
IgG1 deficiency results in hypogammaglobulinemia. IgG2 deficiency increases susceptibility to bacterial infections, IgG3 mediates effector functions and IgG4 is associated with asymptomatic infection. IgG antibodies have enormous therapeutic potential and the Fc region is for the development of therapeutic antibody.
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delipidized
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Antibodies reacting with human immunoglobulin in sera from autoimmune thyroid disease patients as a risk factor for false positive results in IgA assessment
Haroun M and El-Masry MH
Central European Journal of Immunology, 33, 208-212 (2008)
Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases
Irani V, et al.
Molecular Immunology, 67 (2015)
Structure and function of immunoglobulins.
Schroeder Jr H W and Cavacini L
The Journal of Allergy and Clinical Immunology, 125(2), S41-S52 (2010)
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These
Pediatrics international : official journal of the Japan Pediatric Society, 42(4), 337-342 (2000-09-15)
Maternal immunoglobulin G (IgG), transferred across the placenta to the fetus during intrauterine life, is an important component of the neonatal immunological defence mechanisms against infection. There is controversy with respect to differences in placental transfer of the different IgG
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