I5278
Insulin-Like Growth Factor Binding Protein-3 human
recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)
동의어(들):
IGF Binding Protein-3, IGFBP-3
로그인조직 및 계약 가격 보기
크기 선택
25 μG
₩1,139,338
₩1,139,338
구입 가능 여부는 고객센터에 문의하십시오.
모든 사진(1)
크기 선택
보기 변경
25 μG
₩1,139,338
About This Item
₩1,139,338
구입 가능 여부는 고객센터에 문의하십시오.
추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in NSO cells
분석
≥95% (SDS-PAGE)
양식
lyophilized powder
효능
0.01-0.25 μg/mL
분자량
29 kDa
포장
pkg of 25 μg
저장 조건
avoid repeated freeze/thaw cycles
기술
cell culture | mammalian: suitable
불순물
endotoxin, tested
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... IGFBP3(3486)
생화학적/생리학적 작용
Human IGFBP-3 is the major insulin-like growth factor (IGF) binding protein in plasma, where it exists in a ternary complex with IGF-I or IGF-II and the acid-labile subunit (ALS).
IGFBPs (insulin like growth factor binding proteins) regulate bioavailability of IGFs (insulin like growth factors) in cells. Binding between IGFs and IGFBPs reduces the availability of the IGFs. However, IGFBPs also concentrate IGFs in specific areas to potentiate their effects at right time.[1] IGFBP3 binds to IGF-1.[2] It is a tumor suppressor and is downregulated in many cancers.[3] In serum, IGFs, IGFBP3 and the acid labile subunit (ALS) exist together as a complex. This complex is important for increasing the half life of serum IGFs.[4]
물리적 형태
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA.
분석 메모
The biological acitivity is measured as the ability to inhibit the biological activity of 14 ng/ml recombinant human IGF-I on MCF-7 cells.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
개인 보호 장비
dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Chuan-Wei Yang et al.
Journal of the American Medical Directors Association, 16(5), 365-370 (2014-12-31)
Previous studies have demonstrated the polymorphisms of insulinlike growth factor-1 (IGF-1) and its binding protein-3 (IGFBP3) genes could affect the circulating IGF-1 level. Moreover, the serum IGF-1 level was correlated with muscle size. This study aimed to explore the effect
Min Sun Kim et al.
Molecular and cellular biochemistry, 403(1-2), 107-113 (2015-02-11)
Nuclear factor-kappaB (NF-κB) is a transcription factor that is activated in various neoplasms, including gastric cancer. Insulin-like growth factor binding protein-3 (IGFBP-3) is a potent tumor suppressor and is significantly suppressed in a variety of cancers. Although IGFBP-3 has been
Kelley, K.M., et al.
The International Journal of Biochemistry & Cell Biology, 28, 619-637 (1995)
Spagnoli, A. and Rosenfeld, R.G.
Curr. Op. Endocrinology and Diabetes, 4, 1-1 (1997)
Shoshana Yakar et al.
The Journal of clinical investigation, 110(6), 771-781 (2002-09-18)
IGF-1 is a growth-promoting polypeptide that is essential for normal growth and development. In serum, the majority of the IGFs exist in a 150-kDa complex including the IGF molecule, IGF binding protein 3 (IGFBP-3), and the acid labile subunit (ALS).
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.
