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G4251

Sigma-Aldrich

L-Glutathione reduced

≥98.0%

동의어(들):

Glutathione-SH, γ-L-Glutamyl-L-cysteinyl-glycine, GSH

로그인조직 및 계약 가격 보기

크기 선택

10 MG
₩53,897
300 MG
₩59,885
1 G
₩70,035
5 G
₩135,300
10 G
₩206,553
25 G
₩358,803
50 G
₩669,697
100 G
₩1,202,775
250 G
₩2,553,639
500 G
₩4,832,009

₩53,897

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청
모든 사진(10)

크기 선택

보기 변경
10 MG
₩53,897
300 MG
₩59,885
1 G
₩70,035
5 G
₩135,300
10 G
₩206,553
25 G
₩358,803
50 G
₩669,697
100 G
₩1,202,775
250 G
₩2,553,639
500 G
₩4,832,009

About This Item

Linear Formula:
H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
CAS Number:
70-18-8
Molecular Weight:
307.32
Beilstein:
1729812
EC Number:
200-725-4
MDL number:
MFCD00065939
UNSPSC 코드:
12352209
PubChem Substance ID:
24895164
NACRES:
NA.26

₩53,897

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

제품명

L-Glutathione reduced, ≥98.0%

Quality Level

300

분석

≥98.0%

양식

powder

색상

white

mp

192-195 °C (dec.) (lit.)

solubility

water: 50 mg/mL, clear, colorless

응용 분야

detection

작용기

amine
carboxylic acid
thiol

저장 온도

2-8°C

SMILES string

N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O

InChI

1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

InChI key

RWSXRVCMGQZWBV-WDSKDSINSA-N

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Amino Acid Sequence

γ-Glu-Cys-Gly

일반 설명

Glutathione (GSH) is a ubiquitous molecule found in many cells and tissues. The three amino acids present in GSH are glycine, cysteine, and glutamic acid.[1]

애플리케이션

L-Glutathione (GSH) reduced has been used in the elution buffer to elute GST (glutathione S-transferase)-fused proteins using glutathione-agarose beads.[2][3] It has been used to prepare a standard curve for GSH analyses.[4]
May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

생화학적/생리학적 작용

Glutathione (GSH) forms conjugates with various metabolites and xenobiotics. It acts as an important co-factor for various enzymes. GSH is involved in many metabolic and signaling pathways. Glutathione functions as a thiol buffer for cellular proteins like thioredoxins and metallothioneins. GSH is also involved in the regeneration of antioxidants like tocopherols and ascorbate.[1]
Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

기타 정보

For additional information on our range of Biochemicals, please complete this form.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
0000420053
0000420053
0000416029
0000416040
0000416028

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COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Hee Woong Yang et al.
FEBS letters, 593(15), 2060-2068 (2019-06-11)
Ribosomal protein S3 (rpS3) has endonuclease activity for DNA repair. In particular, rpS3 cleaves the phosphodiester bonds of damaged DNA. In this study, we show that the repair domain of rpS3 spans amino acids 144-189. We fused rpS3 with the
Nitric oxide as an independent regulatory factor in regenerating rat liver.
Tuncyurek P, et al.
Acta Chirurgica Belgica, 106, 581-581 (2006)
Cu 2 O/NiO x/graphene oxide modified glassy carbon electrode for the enhanced electrochemical oxidation of reduced glutathione and nonenzyme glucose sensor.
Yuan B et al.
Electrochimica Acta, 104, 78-78 (2013)
Surface Plasmon Resonance (SPR) Analysis of Binding Interactions of Inner-Ear Proteins.
Drescher DG, et al.
Methods in Molecular Biology, 1427, 165-165 (2016)
Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains.
Song KS, et al.
The Journal of Biological Chemistry, 271, 9690-9690 (1996)
모든 관련된 서류 보기

문서

Amino Acid Codon Wheel

Amino Acid Codon Wheel for fast RNA translation. Find which amino acid is translated from your RNA sequence quickly and easily.

Mitochondrial Stress and ROS

Cellular oxidative stress is countered by enzymatic scavengers and antioxidant modulators against reactive oxygen species damage.

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

질문

1–8 / 8 질문  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 답변

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 답변

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Can an aqueous solution of L-Glutathione be autoclaved?

    1 답변

    1. L-Glutathione Reduced aqueous solutions should not be autoclaved as the high temperature and pressure during autoclaving can degrade the compound. It is recommended to filter-sterilize the solution using a sterile filter with a pore size of 0.2 micrometers.

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  4. Is glutathione (reduced) safe to store at room temperature in the powder format? I mistakenly stored it at room temperature for ~ 1 month.

    1 답변

    1. This product is stored at 2-8°C but is stable for short periods at room temperature. The items ship at ambient temperature and are stable for up to 2 weeks without refrigeration. The stability of the material beyond 2 weeks has not been evaluated. The end user would have to determine the suitability for specific applications experimentally.

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  5. After reconstitution, what temperature should the L-glutathione reduced be stored at?

    1 답변

    1. The stability of the product in solution has not been determined. However, it is recommended to prepare solutions fresh for best results.

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  6. What is the solution stability of Product G4251, L-Glutathione reduced?

    1 답변

    1. Aqueous solutions readily oxidize in air to oxidized glutathione, GSSG.  Half-lives of reduced glutathione in solution at various pHs and temperatures have been reported.  The half-life of reduced glutathione is increased in the presence of a chelating agent.  For supporting references, please consult the product information sheet (under Documents, above).

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  7. How do I solubilize Product G4251, L-Glutathione reduced?

    1 답변

    1. Reduced glutathione is freely soluble in water, dilute alcohol, liquid ammonia, and DMF.

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  8. What is the Department of Transportation shipping information for this product?

    1 답변

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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