I0516

Insulin solution from bovine pancreas

10 mg/mL insulin in 25  mM HEPES, pH 8.2, BioReagent, sterile-filtered, suitable for cell culture

• 동의어(들): Bovine insulin, Cell culture grade insulin
• CAS Number: 11070-73-8
• MDL number: MFCD00131380
• UNSPSC 코드: 12352209
• NACRES: NA.77

속성

• 무균: sterile-filtered
• 제품 라인: BioReagent
• 형태: solution
• 농도: 10 mg/mL insulin in 25 mM HEPES, pH 8.2
• 기술: cell culture | mammalian: suitable; single cell analysis: suitable
• 불순물: endotoxin, tested
• pH: 7.9-8.5
• UniProt 수납 번호: P01317
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/2C97H151N25O34S4/c2*1-12-46(10)77(120-72(131)35-98)96(154)122-76(45(8)9)94(152)107-55(24-28-74(134)135)79(137)104-53(22-26-69(100)128)82(140)116-66(40-159)93(151)118-64(38-157)90(148)103-47(11)78(136)114-63(37-124)89(147)121-75(44(6)7)95(153)119-67(41-160)92(150)115-62(36-123)88(146)109-57(30-43(4)5)84(142)110-58(31-48-13-17-50(125)18-14-48)85(143)105-52(21-25-68(99)127)80(138)108-56(29-42(2)3)83(141)106-54(23-27-73(132)133)81(139)112-60(33-70(101)129)87(145)111-59(32-49-15-19-51(126)20-16-49)86(144)117-65(39-158)91(149)113-61(97(155)156)34-71(102)130/h2*13-20,42-47,52-67,75-77,123-126,157-160H,12,21-41,98H2,1-11H3,(H2,99,127)(H2,100,128)(H2,101,129)(H2,102,130)(H,103,148)(H,104,137)(H,105,143)(H,106,141)(H,107,152)(H,108,138)(H,109,146)(H,110,142)(H,111,145)(H,112,139)(H,113,149)(H,114,136)(H,115,150)(H,116,140)(H,117,144)(H,118,151)(H,119,153)(H,120,131)(H,121,147)(H,122,154)(H,132,133)(H,134,135)(H,155,156)/t2*46-,47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,75-,76-,77-/m00/s1
• InChI key: XYPANFGXFLOTDK-CJLNJPJHSA-N
• 유전자 정보: bovine ... INS(280829) ; cow ... INS(280829)

설명

애플리케이션

Insulin solution from bovine pancreas has been used:

• to study the effect of exogenous insulin on plasma concentrations of glucose, insulin, insulin-like growth factor I (IGF-I), and progesterone (P4) in pubertal beef heifers
• to study the insulin responsiveness of the placenta during pregnancy complications using primary human trophoblast cells and placental villous explants
• to study the effect of insulin receptor signaling dendritic spine density in neonatal mouse hippocampal neurons in vitro

생화학적/생리학적 작용

Insulin is a major glucose-lowering hormone, insufficiency of which causes hyperglycemia observed in type 2 diabetes.

Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

물리적 형태

stable 2-8 °C

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves