추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in E. coli
분석
≥98% (SDS-PAGE and HPLC)
형태
lyophilized powder
효능
≤2.0 ng/mL ED50
품질
endotoxin tested
분자량
7.5 kDa
포장
pkg of 5X50 μg
pkg of 50 μg
기술
cell culture | mammalian: suitable
불순물
≤0.1 EU/μg
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... IGF2(3481)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
생화학적/생리학적 작용
Insulin-like growth factor II (IGF-II) also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. Expression of IGF-II is highest in fetal tissues, where it is believed to play a major role in overall growth and development. After birth IGF-II expression decreases to much lower levels in a variety of tissues. IGF-II is produced also in several tumors. IGF-II binds to IGF-II receptor (IGF-IIR), to IGF-IR and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-IR. However, during embryogenesis the roles of both IGF-IIR and IR may be significant in promoting normal growth.
물리적 형태
Lyophilized from a 0.2 μm filtered solution with no additives.
분석 메모
The biological activity is measured by a cell proliferation assay using mouse FDC-P1
관련 제품
제품 번호
설명
가격
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Yongming Yuan et al.
Scientific reports, 7(1), 78-78 (2017-03-03)
Insulin-like growth factors (IGFs) regulate diverse processes including energy metabolism, cell proliferation and embryonic development. They activate the IGF signaling pathway via binding to cell surface receptors. Here we report an essential role of IGF2 in maintaining the pluripotency of
Chidambaram Ramanathan et al.
Methods in molecular biology (Clifton, N.J.), 1755, 49-64 (2018-04-20)
In mammals, many aspects of metabolic, physiological, and behavioral processes are regulated by endogenous circadian clocks. Oscillators of different tissue types share a common molecular mechanism at the cellular and molecular level which underlies the rhythmic expression of genes. Individual
Jasmin Svinka et al.
Journal of molecular medicine (Berlin, Germany), 95(1), 109-117 (2016-08-29)
We have demonstrated that the signal transducer and activator of transcription 3 (STAT3) protects from cholestatic liver injury. Specific ablation of STAT3 in hepatocytes and cholangiocytes (STAT3∆hc) aggravated liver damage and fibrosis in the Mdr2-/- (multidrug resistance 2) mouse model
Şeyda Berk et al.
Frontiers in oncology, 11, 645732-645732 (2021-07-23)
There are only a few experimental studies which have investigated effects of glucose alone, and glucose in combination with insulin/insulin-like growth factors (IGF) on the growth of colon cancer. In the present study, we studied in vitro in human colorectal
Till Seime et al.
Cells, 10(6) (2021-06-03)
Calcification is a prominent feature of late-stage atherosclerosis, but the mechanisms driving this process are unclear. Using a biobank of carotid endarterectomies, we recently showed that Proteoglycan 4 (PRG4) is a key molecular signature of calcified plaques, expressed in smooth
문서
Insulin-like Growth Factors (IGF)
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