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H8891

Sigma-Aldrich

Heparinase III from Flavobacterium heparinum

Lyophilized powder stabilized with approx. 25% (w/w) bovine serum albumin, ≥30 units/mg protein (enzyme + BSA)

동의어(들):

Heparin Lyase III, Heparitinase I, Heparitinase from Flavobacterium heparinum

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크기 선택

5 UNITS
₩472,889
10 UNITS
₩766,528
50 UNITS
₩2,768,616

₩472,889

출고 가능일2025년 4월 02일세부사항

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보기 변경
5 UNITS
₩472,889
10 UNITS
₩766,528
50 UNITS
₩2,768,616

About This Item

CAS Number:
37290-86-1
효소 위원회 번호:
4.2.2.8 (BRENDA, IUBMB)
MDL number:
MFCD00131319
UNSPSC 코드:
12352204
NACRES:
NA.54

₩472,889

출고 가능일2025년 4월 02일세부사항

생물학적 소스

bacterial (Flavobacterium heparinum)

Quality Level

200

결합

conjugate (Glucosaminoglycan)

양식

lyophilized powder

특이 활성도

≥30 units/mg protein (enzyme + BSA)

분자량

70.8 kDa

응용 분야

diagnostic assay manufacturing

저장 온도

−20°C

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애플리케이션

Heparinase III from Flavobacterium heparinum has been used to cleave specific GAGs.[1][2] It has been used to study its effect on the electrophoretic mobility of the protein reacting with the anti-aFGF (acidic fibroblast growth factor) antibody.[3]

생화학적/생리학적 작용

Heparin-degrading lyase that recognizes heparin sulfate proteoglycan as its primary substrate.
Heparinase III prevents the formation of new blood vessels in vivo.[4] It specifically degrades heparin sulphate at the HNY-I and HNY,6X-G2 links. Unlike other heparinise, heparinase III does not contain the amino acid cysteine. It contains 13 histidine residues, which is responsible for its catalytic action.[5] This enzyme is not active towards heparin or low molecular weight heparins.

단위 정의

One unit will form 0.1 μmole of unsaturated uronic acid per hr at pH 7.5 at 25 °C. One International Unit (I.U.) is equivalent to approx. 600 Sigma units. Package sizes are sold in Sigma units.

기타 정보

View more information on enzymes for complex carbohydrate analysis at www.sigma-aldrich.com/enzymeexplorer

픽토그램

Health hazard
GHS08

신호어

Danger

유해 및 위험 성명서

H334

예방조치 성명서

P261 - P284 - P501

Hazard Classifications

Resp. Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
0000422666
0000422655
0000422645
0000422655
0000422645

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

FGF binding by extracellular matrix components of Wharton's jelly
Malkowski A, et al.
Acta Biochimica Polonica, 54(2), 357-357 (2007)
Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction
Toh YC and Voldman J
Faseb Journal, 25(4), 1208-1217 (2011)
Erin M Smith et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(51), 21683-21688 (2009-12-08)
Platelet-derived growth factor (PDGF) signaling is essential for processes involving cell motility and differentiation during embryonic development in a wide variety of organisms including the mouse, frog, zebrafish, and sea urchin. In early Xenopus laevis embryos, PDGF-AA provides guidance cues
Composition of the endothelial glycocalyx and its relation to its thickness and diffusion of small solutes
Gao L and Lipowsky HH
Microvascular Research, 80(3), 394-401 (2010)
Andrea Garolla et al.
Human reproduction (Oxford, England), 27(4), 967-973 (2012-02-09)
Human papillomavirus (HPV) infection has been demonstrated in the sperm of a large percentage of sexually active males and is associated with an impairment of sperm parameters, with a particular negative impact on sperm motility, suggesting a possible role in
모든 관련된 서류 보기

문서

Glycosaminoglycans and Proteoglycans

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

질문

1–3 / 3 질문  

  1. Does Product No. H8891, Heparinase III, contain calcium?

    1 답변

    1. This product is lyophilized from a solution which is 75 mM NaCl/ 5mM NaH2PO4. We have no reason to believe that calcium ions are present.

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  2. Is Product No. H8891, Heparinase III sold based on Sigma Units or International Units?

    1 답변

    1. This material is sold based on Sigma Units.  One Sigma Unit will form 0.1 μmole of unsaturated uronic acid per hr at pH 7.5 at 25 °C. One International Unit (I.U.) is equivalent to approx. 600 Sigma units.

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  3. What is the Department of Transportation shipping information for this product?

    1 답변

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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