H7640

Heparan sulfate sodium salt from bovine kidney

powder, extracellular matrix component

• 동의어(들): Heparitin sulfate sodium salt
• CAS Number: 57459-72-0
• MDL number: MFCD00131294
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 제품명: Heparan sulfate sodium salt from bovine kidney,
• 저장 온도: 2-8°C

설명

애플리케이션

Heparan sulfate sodium salt from bovine kidney has been used:

• to investigate its effect on proliferation of B cells[1]
• to monitor its role on eye development in E5 embryonic cells[2]
• to study its binding with exosome fibronectin in human trabecular meshwork cells using dot blot[3]

생화학적/생리학적 작용

Constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion

Heparan sulphate (HS), a ubiquitous glycosaminoglycan, is a polymer of D-glucuronic acid or L-iduronic acid and D-glucosamine (GlcA) sugars.[4] It is synthesized in the cis-Golgi as heparan. In Golgi, final heparan sulphate is synthesized in by the action of enzymes N- and O-HS-sulphotransferases and HS epimerase. The mature HS has 50 to 200 disaccharide units.[5] It is part of the extracellular matrix (ECM) and plays a key role in the oncogenic pathway. Deregulation of heparin sulfate metabolism is implicated in cancer progression.[6] HS is associated with the onset of infectious diseases and inflammatory conditions.[7] HS interaction with Aβ fibrils contributes to the pathophysiology of Alzheimer′s disease.[8]Heparan sulphate is a constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)