G3381

Geldanamycin from Streptomyces hygroscopicus

≥98% (HPLC), powder

• 동의어(들): NSC 122750
• 실험식(Hill 표기법): C₂₉H₄₀N₂O₉
• CAS Number: 30562-34-6
• Molecular Weight: 560.64
• MDL number: MFCD00274570
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329799914
• NACRES: NA.77

속성

• 무균: non-sterile
• Quality Level: 300
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: yellow to orange
• solubility: DMSO: soluble
• 항생제 활성 스펙트럼: neoplastics
• 동작 모드: enzyme | inhibits
• 저장 온도: −20°C
• SMILES string: CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O
• InChI: 1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
• InChI key: QTQAWLPCGQOSGP-KSRBKZBZSA-N

설명

일반 설명

Chemical structure: benzenoid

생화학적/생리학적 작용

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

특징 및 장점

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)