T3434

Tyrphostin AG 490

solid

• 동의어(들): 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
• 실험식(Hill 표기법): C₁₇H₁₄N₂O₃
• CAS Number: 133550-30-8
• Molecular Weight: 294.30
• MDL number: MFCD00236452
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278732
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 형태: solid
• 색상: yellow
• solubility: DMSO: soluble 10 mg/ml, clear, yellow; ethanol: 5 mg/mL; H₂O: insoluble
• 저장 온도: −20°C
• SMILES string: Oc1ccc(cc1O)\C=C(/C#N)C(=O)NCc2ccccc2
• InChI: 1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
• InChI key: TUCIOBMMDDOEMM-RIYZIHGNSA-N
• 유전자 정보: human ... EGFR(1956) , ERBB2(2064) , IL2(3558) , JAK2(3717)

설명

애플리케이션

Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity⁵. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells⁶.

생화학적/생리학적 작용

Jak-2 protein tyrosine kinase (PTK) inhibitor. Inhibits interleukin 2 (IL-2) driven mitogenesis and triggers apoptosis of tumor cells in Sezary syndrome, a leukemic variant of cutaneous T cell lymphoma.

특징 및 장점

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

주의사항

Photosensitive

제조 메모

Tyrphostin AG 490 is soluble in ethanol at 5 mg/ml and is insoluble in water. It is also soluble in DMSO at 10 mg/ml and yields a clear, yellow solution.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3