G6649

Genistein

≥98% (HPLC), powder, tyrosine protein kinase inhibitor

• 동의어(들): 4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• 실험식(Hill 표기법): C₁₅H₁₀O₅
• CAS Number: 446-72-0
• Molecular Weight: 270.24
• Beilstein: 263823
• EC Number: 207-174-9
• MDL number: MFCD00016952
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278036
• NACRES: NA.77

속성

• 제품명: Genistein, synthetic, ≥98% (HPLC), powder
• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: off-white to yellow
• mp: 297.0-298.0 °C
• solubility: DMSO: soluble; ethanol: soluble
• 저장 온도: −20°C
• SMILES string: Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
• InChI key: TZBJGXHYKVUXJN-UHFFFAOYSA-N
• 유전자 정보: human ... AKT1(207) , CYP19A1(1588) , EGFR(1956) , ESR1(2099) , ESR2(2100) ; mouse ... Esr1(13982) , Hexa(15211) ; rat ... Adora1(29290) , Adora2a(25369) , Ar(24208)

설명

일반 설명

Genistein is an isoflavonoid present among Leguminosae family of plants. It is structurally similar to estrogen (estradiol-17β).[1]

애플리케이션

Genistein has been used:

• as a test compound to access its estrogeniic acivity[2]
• as an oestrogenic ligand to carry out identical reporter gene activation assays and also used to examine the binding of genistein to hERβ[3]
• as an endocytosis inhibitor to test the possible effect of endocytosed advanced glycation end - bovine serum albumin (AGE-BSA) on lysosomes[4]

생화학적/생리학적 작용

Genistein is essential for plant-microbe interaction. It acts as a natural chemoprotectant and helps in preventing tumor progression and heart disorders. Genistein functionally shares estrogen′s action. It is useful in evaluating nutraceuticals and functional foods. Genistein exhibits antimicrobial action and can serve as a phytoalexin and phytoanticipin.[1]

Inhibitor of tyrosine protein kinase; competitive inhibitor of ATP in other protein kinase reactions. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis.

특징 및 장점

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Chloride Channels and Met pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

제조 메모

Genistein is soluble in DMSO and ethanol. It is also soluble in chlorform:methanol (1:1 (v:v), 10 mg/ml).

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type N95 (US)