D1916

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside

≥98% (HPLC), powder, RNA synthesis inhibitor

• 동의어(들): 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, 5,6-Dichlorobenzimidazole riboside, DRB
• 실험식(Hill 표기법): C₁₂H₁₂Cl₂N₂O₄
• CAS Number: 53-85-0
• Molecular Weight: 319.14
• Beilstein: 39123
• MDL number: MFCD00036785
• UNSPSC 코드: 12352200
• eCl@ss: 32151902
• PubChem Substance ID: 24278361
• NACRES: NA.77

속성

• 제품명: 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside,
• 양식: powder
• Quality Level: 200
• 저장 온도: −20°C
• SMILES string: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3cc(Cl)c(Cl)cc23
• InChI: 1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
• InChI key: XHSQDZXAVJRBMX-DDHJBXDOSA-N
• 유전자 정보: human ... CSNK2A1(1457) , CSNK2B(1460)

설명

애플리케이션

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside has been used:

• as an inhibitor of RNA polymerase II in mouse melanoma cells[1]
• for the inhibition of cyclin D1 mRNA synthesis in human prostate epithelial cell lines[2]
• in the inhibition of interleukin-2 gene transcription in Jurkat cells[3]

생화학적/생리학적 작용

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), a nucleoside analog that halts mRNA synthesis[4] by phosphorylation of the C-terminal domain of RNA polymerase II, making it inactive.[5] It also interferes with the DNA topoisomerase II, may modulate response to cytokines and blocks the human immunodeficiency virus (HIV) via RNA modification.[6] It also inhibits cyclin-dependent kinases (CDKs) 7 and 9 and favors apoptosis in leukemic cells. It may serve as a therapeutic agent in treating cancer.[7]

Inhibitor of RNA synthesis; causes premature termination of transcription. CK2 (casein kinase-2) inhibitor.

특징 및 장점

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable