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T3652

Sigma-Aldrich

Triptolide

from Tripterygium wilfordii, ≥98% (HPLC), solid, immunosuppressant

동의어(들):

PG 490

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크기 선택

1 MG
₩396,053
5 MG
₩1,097,317

₩396,053

예상 입고일2025년 4월 14일세부사항

벌크 견적 요청
모든 사진(3)

크기 선택

보기 변경
1 MG
₩396,053
5 MG
₩1,097,317

About This Item

실험식(Hill 표기법):
C20H24O6
CAS Number:
38748-32-2
Molecular Weight:
360.40
MDL number:
MFCD00210565
UNSPSC 코드:
12352200
PubChem Substance ID:
24900156
NACRES:
NA.77

₩396,053

예상 입고일2025년 4월 14일세부사항

벌크 견적 요청

제품명

Triptolide, from Tripterygium wilfordii, ≥98% (HPLC), solid

생물학적 소스

Tripterygium wilfordii

분석

≥98% (HPLC)

양식

solid

색상

white to off-white

solubility

DMSO: soluble

저장 온도

2-8°C

SMILES string

O=C1OCC2=C1CC[C@]3(C)[C@]4(O5)[C@@H]5[C@H]6[C@@](O6)(C(C)C)[C@@H](O)[C@]4(O7)[C@@H]7C[C@]32[H]

InChI

1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

InChI key

DFBIRQPKNDILPW-KTGKZQHOSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

Triptolide has been used as a NF-κB inhibitor to study the inhibition of cell invasion and angiogenesis in human thyroid cancer cells6. Triptolide has also been used to study its apoptotic effects in anaplastic thyroid cancer cells7.

생화학적/생리학적 작용

Triptolide is a diterpene triepoxide, the principal active ingredient in extracts from the Chinese herb Tripterygium wilfordii hook (TwHF). It is a potent immunosuppressant and anti-inflammatory. Triptolide has been shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. It synergizes with cyclosporin A in promoting graft survival in animal models and in suppression of graft versus host disease in allogeneic bone marrow transplants. In addition, it induces apoptosis in tumor cells and potentiates tumor necrosis factor (TNFα) induction of apoptosis in part through the suppression of c-IAP2 and c-IAP1 induction.

제조 메모

Triptolide is soluble in DMSO. The stock solution should be stored in DMSO at -20 deg C after reconstitution.

픽토그램

Skull and crossbonesHealth hazard
GHS06,GHS08

신호어

Danger

유해 및 위험 성명서

H300 + H330,H361f

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
WXBF2598V
WXBF4357V
WXBF0132V
WXBD4606V
WXBD6758V

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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Ruidong Li et al.
Oncology reports, 37(1), 442-448 (2016-11-24)
Cellular senescence, an irreversible growth arrest of cells, is involved in protection against cancer. Triptolide (TPL) plays an important role in immunosuppressive, anti-fertility, anti-cystogenesis and anticancer activities. However, effect and mechanism of TPL on cellular senescence-associated antitumor is rarely reported.
Chen Chen et al.
Nucleic acids research, 47(13), 6714-6725 (2019-05-28)
SPT6 is a conserved elongation factor that is associated with phosphorylated RNA polymerase II (RNAPII) during transcription. Recent transcriptome analysis in yeast mutants revealed its potential role in the control of transcription initiation at genic promoters. However, the mechanism by
Xiang Wang et al.
Toxicology and applied pharmacology, 310, 32-40 (2016-08-25)
Triptolide (TP), derived from the medicinal plant Triterygium wilfordii Hook. f. (TWHF), is a diterpene triepoxide with variety biological and pharmacological activities. However, TP has been restricted in clinical application due to its narrow therapeutic window especially in reproductive system.
Chundong Song et al.
BMC complementary and alternative medicine, 19(1), 198-198 (2019-08-04)
Endothelial cell inflammation is a central event in the pathogenesis of numerous cardiovascular diseases, including sepsis and atherosclerosis. Triptolide, a principal bioactive ingredient of Traditional Chinese Medicine Tripterygium wilfordii Hook.F., displays anti-inflammatory actions in vivo. However, the mechanisms underlying these
Yanlong Yang et al.
International immunopharmacology, 41, 8-16 (2016-11-07)
Triptolide, a primary active ingredient extracted from a traditional Chinese herb, Tripterygium wilfordii Hook F, has been demonstrated to have a positive therapeutic effect on patients with rheumatoid arthritis (RA); however, its mechanism of action against RA is not well
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