모든 사진(1)

문서

C4493

Cucurbitacin I hydrate

Name: Cucurbitacin I hydrate
Brand: SIGMA

≥95% (HPLC), solid

동의어(들):

2,16α,20,25-Tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione, Elatericin B, JSI-124, NSC 521777

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모든 사진(1)

About This Item

실험식(Hill 표기법):

C₃₀H₄₂O₇ · xH₂O

CAS Number:

2222-07-3

Molecular Weight:

514.65 (anhydrous basis)

EC Number:

218-736-8

UNSPSC 코드:

12352200

PubChem Substance ID:

329775065

NACRES:

NA.77

추천 제품

Slide 1 of 10

1 of 10

Sigma-Aldrich

238590

Cucurbitacin I, Cucumis sativus L.

Sigma-Aldrich

C8499

Cucurbitacin B hydrate

Sigma-Aldrich

SML0577

Cucurbitacin E

PHL89464

Cucurbitacin I

PHL82226

Cucurbitacin B

PHL82510

Cyclopamine

Sigma-Aldrich

C2294

Cod liver oil fatty acid methyl esters

Y0001976

Deferiprone

Sigma-Aldrich

M3650

Methyl myristoleate

Sigma-Aldrich

L2037

β-Lapachone

Quality Level

100

분석

≥95% (HPLC)

형태

solid

색상

white to off-white

solubility

DMSO: >5 mg/mL

저장 온도

−20°C

SMILES string

O.CC(C)(O)\C=C\C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C

InChI

1S/C30H42O7.H2O/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6;/h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3;1H2/b12-11+;/t17-,19-,20+,23+,27+,28-,29+,30+;/m1./s1

InChI key

ZKDSPEWKSJCXQE-NEBRQAMTSA-N

생화학적/생리학적 작용

Cucurbitacin I (JSI-124) is a novel selective inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway with anti-proliferative and anti-tumor properties.

특징 및 장점

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

픽토그램

GHS06

신호어

Danger

유해 및 위험 성명서

H300

예방조치 성명서

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 1 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

이미 열람한 고객

Slide 1 of 9

1 of 9

Sigma-Aldrich

573096

STAT3 Inhibitor Peptide, Cell-Permeable

Sigma-Aldrich

SML1505

AZD1480

Sigma-Aldrich

F9057

FLLL31

Sigma-Aldrich

SML0330

S3I-201

Sigma-Aldrich

C5624

Cryptotanshinone

PHL80075

α-Chaconine

Sigma-Aldrich

S3757

α-Solanine

Sigma-Aldrich

T3434

Tyrphostin AG 490

Sigma-Aldrich

SMB00148

Elaterinide

Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma--derived CD44(+)ALDH1(+) cells.

Yi-Wei Chen et al.

Molecular cancer therapeutics, 9(11), 2879-2892 (2010-11-11)

Head and neck squamous cell carcinoma (HNSCC) is a prevalent cancer worldwide. Signal transducers and activators of transcription 3 (STAT3) signaling is reported to promote tumor malignancy and recurrence in HNSCC. Cucurbitacins, triterpenoid derivatives, are strong STAT3 inhibitors with anticancer

Self-associating poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer for the solubilization of STAT-3 inhibitor cucurbitacin I.

Abdullah Mahmud et al.

Biomacromolecules, 10(3), 471-478 (2009-01-30)

An increase in the degree of chemical compatibility between drug and polymeric structure in the core has been shown to raise the encapsulation efficiency and lower the rate of drug release from polymeric micelles. In this study, to achieve an

Development of a poly(d,l-lactic-co-glycolic acid) nanoparticle formulation of STAT3 inhibitor JSI-124: implication for cancer immunotherapy.

Ommoleila Molavi et al.

Molecular pharmaceutics, 7(2), 364-374 (2009-12-25)

Constitutively activated signal transducer and activator of transcription-3 (STAT3) in tumor and dendritic cells (DCs) plays a critical role in tumor-induced immunosuppression. This is considered a major challenge in effective immunotherapy of cancer. Herein we describe the development of a

Reactive Myelopoiesis Triggered by Lymphodepleting Chemotherapy Limits the Efficacy of Adoptive T Cell Therapy.

Patrick Innamarato et al.

Molecular therapy : the journal of the American Society of Gene Therapy, 28(10), 2252-2270 (2020-07-03)

Adoptive T cell therapy (ACT) in combination with lymphodepleting chemotherapy is an effective strategy to induce the eradication of tumors, providing long-term regression in cancer patients. Despite that lymphodepleting regimens condition the host for optimal engraftment and expansion of adoptively transferred

Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity.

Trisha R Stankiewicz et al.

The Journal of biological chemistry, 287(20), 16835-16848 (2012-03-02)

In several neuronal cell types, the small GTPase Rac is essential for survival. We have shown previously that the Rho family GTPase inhibitor Clostridium difficile toxin B (ToxB) induces apoptosis in primary rat cerebellar granule neurons (CGNs) principally via inhibition

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문서

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

문서

Cucurbitacin I hydrate

≥95% (HPLC), solid

About This Item

추천 제품

속성

Quality Level

분석

형태

색상

solubility

저장 온도

SMILES string

InChI

InChI key

관련 카테고리

설명

생화학적/생리학적 작용

특징 및 장점

안전성 정보

픽토그램

신호어

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

개인 보호 장비

문서

시험 성적서(COA)

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