추천 제품
생물학적 소스
synthetic (organic)
분석
≥99% (TLC)
양식
powder
색상
white
solubility
ethanol: 10 mg/mL
저장 온도
2-8°C
SMILES string
Cl.Clc1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3
InChI
1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChI key
ZNRYCIVTNLZOGI-UHFFFAOYSA-N
유전자 정보
human ... SLC2A1(6513) , SLC2A4(6517)
애플리케이션
생화학적/생리학적 작용
ML-9 is myosin light chain kinase inhibitor. It inhibits insulin-induced translocation of glucose transporters GLUT4 and GLUT1 in a dose-dependent manner.[4] ML-9 also inhibits agonist-induced Ca2+ entry into endothelial cells[5] and catecholamine secretion in intact and permeabilized chromaffin cells.[6] ML-9 promotes cell death in cancer cells by triggering accumulation of autophagic vacuoles.[7] ML-9 impacts phosphorylation of myosin light chain kinase and alters trabecular meshwork shape and decreases intraocular pressure in rabbit eyes.[8]
특징 및 장점
This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Effects of ML-9 on insulin stimulation of glucose transport in 3T3-L1 adipocytes.
Inoue G, et al.
The Journal of Biological Chemistry, 268(7), 5272-5278 (1993)
Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection
AntoineTE and Shukla D
Antiviral Therapy, 19(1), 15-29 (2014)
Amy Peng et al.
Neuron, 73(6), 1108-1115 (2012-03-27)
Synaptic vesicle exo- and endocytosis are usually driven by neuronal activity but can also occur spontaneously. The identity and differences between vesicles supporting evoked and spontaneous neurotransmission remain highly debated. Here we combined nanometer-resolution imaging with a transient motion analysis
Letitia Weigand et al.
American journal of physiology. Lung cellular and molecular physiology, 290(2), L284-L290 (2005-09-13)
Endothelin-1 (ET-1), a potent vasoconstrictor, is believed to contribute to the pathogenesis of hypoxic pulmonary hypertension. Previously we demonstrated that contraction induced by ET-1 in intrapulmonary arteries (IPA) from chronically hypoxic (CH) rats occurred independently of changes in intracellular Ca2+
RhoD inhibits RhoC-ROCK-dependent cell contraction via PAK6
Durkin CH, et al.
Developmental Cell, 41(3), 315-329 (2017)
문서
Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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