L7260

Oleoyl-L-α-lysophosphatidic acid sodium salt

≥98%, solid

• 동의어(들): 1-Oleoyl-sn-glycerol 3-phosphate sodium salt, 3-sn-Lysophosphatidic acid, 1-oleoyl sodium salt, LPA sodium salt
• 실험식(Hill 표기법): C₂₁H₄₁O₇P · xNa⁺
• CAS Number: 22556-62-3
• Molecular Weight: 436.52 (free acid basis)
• MDL number: MFCD00133427
• UNSPSC 코드: 12352211
• PubChem Substance ID: 24896456
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥98%
• 양식: solid
• 색상: white
• 지질 유형: phosphoglycerides
• 저장 온도: −20°C
• SMILES string: O[C@](COP([O-])(O)=O)([H])COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]
• InChI: 1S/C21H41O7P.Na.H/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26;;/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26);;/b10-9+;;
• InChI key: CHJOEWDRTPWOCY-TTWKNDKESA-N

설명

일반 설명

Lysophosphatidic acid (LPA) is an essential metabolite for membrane biosynthesis. LPA interacts with the G protein-coupled receptors (GPCRs), called the LPA receptor and mediates signaling.[1] Oleoyl-L-α-lysophosphatidic acid activates the receptor LPA4.[2] In keratinocytes, oleoyl-L-α-lysophosphatidic acid promotes growth to some extent.[3]

애플리케이션

Oleoyl-L-α-lysophosphatidic acid sodium salt has been used:

• for the activation of Ras homolog gene family, member A (RhoA) and expression of claudin-1 in human breast cancer epithelial cell line[4]
• in RH7777 cells for cyclic adenosine monophosphate (cAMP) accumulation assay and calcium mobilisation assay[5]
• in vitro luciferase assay and live-cell imaging[6]

생화학적/생리학적 작용

Endogenous agonist for LPA₁ and LPA₂ receptors. LPA does not induce angiogenesis, but has effects on endothelial cell physiology that are similar to those of sphingosine 1-phosphate. Induces cell migration of cancer and non-cancer cells.

특징 및 장점

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

주의사항

Hygroscopic, photosensitive

제조 메모

Prepared by the action of phospholipase A on L-α-phosphatidic acid, dioleoyl.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)