27840

Corticosterone

≥98.5% (HPLC)

• 동의어(들): 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
• 실험식(Hill 표기법): C₂₁H₃₀O₄
• CAS Number: 50-22-6
• Molecular Weight: 346.46
• Beilstein: 2339601
• EC Number: 200-019-6
• MDL number: MFCD00037715
• UNSPSC 코드: 12352211
• PubChem Substance ID: 57648276
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: ≥98.5% (HPLC)
• 양식: powder or crystals
• 광학 활성: [α]20/D +223±3°, c = 1% in ethanol
• mp: 179-183 °C (lit.); 179-183 °C
• 작용기: ketone
• SMILES string: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• InChI key: OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• 유전자 정보: human ... EBP(10682) , SERPINA6(866) ; rat ... Ar(24208) , Nr3c1(24413)

설명

일반 설명

Corticosterone (Cort) is a glucocorticoid hormone.[1] It is also the principal hormone that mediates stress responses in birds.[2] It is the primary adrenal cortical steroid in rat plasma.[3] The influence of maternal Cort exposure on the developing placenta has been studied in a mouse model.[4]

애플리케이션

Corticosterone was used to study the adrenoceptor signaling in rats,[5][6] lizards[7] or in vitro.[8] It was also used in immune suppression experiment.[9]

생화학적/생리학적 작용

Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. The role of corticosterones is vital for reproductive processes including ovulation, lutenization, development of oocytes, parturition and lactation. The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase.[10][11]

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

제조 메모

Corticosterone is soluble in chloroform and ethanol.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves