C2505

Corticosterone

≥92% (HPLC), powder, corticosteroid hormone

• 동의어(들): 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
• 실험식(Hill 표기법): C₂₁H₃₀O₄
• CAS Number: 50-22-6
• Molecular Weight: 346.46
• Beilstein: 2339601
• EC Number: 200-019-6
• MDL number: MFCD00037715
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24278302
• NACRES: NA.77

속성

• 제품명: Corticosterone, ≥92%
• 생물학적 소스: synthetic (organic)
• 분석: ≥92%
• 양식: powder
• mp: 179-183 °C (lit.)
• solubility: chloroform: 50 mg/mL, clear, colorless to faintly yellow
• 배송 상태: ambient
• 저장 온도: room temp
• SMILES string: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• InChI key: OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• 유전자 정보: human ... EBP(10682) , SERPINA6(866) ; rat ... Ar(24208) , Nr3c1(24413)

설명

애플리케이션

Corticosterone has been used:

• in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice[1]
• as a stress inducing hormone in pregnant mice[2]
• to test its effect on depression-related behaviors in mice[3]

생화학적/생리학적 작용

Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.

Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands.[4] However, it may also be synthesized in non-adrenal tissues including leydig cells of testes[4] and in murine thymus.[5] Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress.[6] It is produced by HPA activation in response to stress in myeloid cells.[7] Elevated levels of corticosterone is observed in Huntington′s disease (HD).[8]

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves