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Merck
모든 사진(1)

문서

481990

Sigma-Aldrich

Nigericin, Sodium Salt, Streptomyces hygroscopicus

Disrupts the membrane potential and stimulates ATPase activity in mitochondria.

동의어(들):

Nigericin, Sodium Salt, Streptomyces hygroscopicus, Antibiotic K178

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C40H67O11 · Na
CAS Number:
28643-80-3
Molecular Weight:
746.94
MDL number:
MFCD00036825
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

100

분석

≥98% (TLC)

형태

lyophilized

제조업체/상표

Calbiochem®

저장 조건

OK to freeze

solubility

chloroform: soluble
ethanol: soluble
ethyl acetate: soluble

배송 상태

ambient

저장 온도

2-8°C

InChI

1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1

InChI key

MOYOTUKECQMGHE-KKCUGXASSA-M

일반 설명

A monocarboxylate that catalyzes the electroneutral exchange of an alkali metal for H+ (antiport). Transports monovalent cations across membranes with the following specificities: K+>Rb+>Cs+>>Na+. An antibiotic that kills bacteria by facilitating the diffusion of ions across membranes. Disrupts the membrane potential and stimulates mitochondrial ATPase activity.
Disrupts the membrane potential and stimulates ATPase activity in mitochondria. Transports monovalent cations across membranes with the following specificity: K+>Rb+>Cs+>>Na+.

생화학적/생리학적 작용

Cell permeable: no
Primary Target
Disrupts the membrane potential and stimulates ATPase activity in mitochondria.
Product does not compete with ATP.
Reversible: no

경고

Toxicity: Toxic (F)

재구성

Following reconstitution, aliquot and freeze. Stock solutions are stable for 1 month at -20°C.

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Moriyama, Y., et al. 1994. J. Biochem.115, 213.
Eytan, G.D., et al. 1990. J. Biol. Chem.265, 12949.
Alonso, M.A., and Carrasco, L. 1981. FEBS Lett.127, 112.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

픽토그램

Skull and crossbones
GHS06

신호어

Danger

유해 및 위험 성명서

H301,H319

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

시험 성적서(COA)

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