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860816P

Avanti

16:0(2S-OH) Ceramide

Avanti Research™ - A Croda Brand 860816P, powder

동의어(들):

N-(2′-(S)-hydroxypalmitoyl)-D-erythro-sphingosine

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크기 선택

5 MG
₩524,248

₩524,248

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모든 사진(1)

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5 MG
₩524,248

About This Item

실험식(Hill 표기법):
C34H67NO4
CAS Number:
890041-50-6
Molecular Weight:
553.90
MDL number:
MFCD22416672
UNSPSC 코드:
12352211
NACRES:
NA.25

₩524,248

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

양식

powder

포장

pkg of 1 × 5 mg (860816P-5mg)

제조업체/상표

Avanti Research™ - A Croda Brand 860816P

지질 유형

sphingolipids

배송 상태

dry ice

저장 온도

−20°C

SMILES string

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@@H](O)CCCCCCCCCCCCCC)=O)CO

InChI

1S/C34H67NO4/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-32(37)31(30-36)35-34(39)33(38)29-27-25-23-21-18-16-14-12-10-8-6-4-2/h26,28,31-33,36-38H,3-25,27,29-30H2,1-2H3,(H,35,39)/b28-26+/t31-,32+,33-/m0/s1

InChI key

YWZGQPJRQXHVQX-UMKNRRHWSA-N

일반 설명

Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis.[1] 16:0(2S-OH) Ceramide is a unique ceramide containing 16C long chain base fatty acid (palmitic acid)-with 2′-hydroxyl group in S configuration.[2]

생화학적/생리학적 작용

Hydroxy fatty acid (hFA)-sphingolipids are implicated in cell signaling.[3] They also facilitate cell differentiation and apoptosis.[2] hFA-ceramides in epidermis help in permeability barrier function. hFA-ceramides are synthesized by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H leads to the development of neurological disorders including leukodystrophy and spastic paraparesis in humans.[3] hFA-ceramides in the cell membrane are essential for PM02734 drug to exhibit its anti-tumor activity.[4]

포장

5 mL Amber Glass Screw Cap Vial (860816P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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시험 성적서(COA)

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문서 라이브러리 방문

2?-Hydroxy ceramide in membrane homeostasis and cell signaling
Kota V and Hama H
Advances in Biological Regulation, 54, 223-230 (2014)
Levels of SCS7/FA2H-mediated fatty acid 2-hydroxylation determine the sensitivity of cells to antitumor PM02734
Herrero AB, et al.
Cancer research, 68(23), 9779-9787 (2008)
Venkatesh Kota et al.
Advances in biological regulation, 54, 223-230 (2013-10-22)
Ceramide is a precursor of complex sphingolipids and also plays important roles in cell signaling. With the advances in lipid analytical technologies, the structural diversity of ceramide species have become evident, and the complexity of cellular metabolism and function associated
Fatty acid 2-Hydroxylation in mammalian sphingolipid biology
Hama H, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1801(4), 405-414 (2010)
Nathan L Alderson et al.
Journal of lipid research, 50(6), 1203-1208 (2009-01-28)
Sphingolipids are ubiquitous components of eukaryotic cells that regulate various cellular functions. In many cell types, a fraction of sphingolipids contain 2-hydroxy fatty acids, produced by fatty acid 2-hydroxylase (FA2H), as the N-acyl chain of ceramide [hydroxyl fatty acid (hFA)-sphingolipids].
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